SMAD6

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SMAD6	SMAD6, AOVD2, HsT17432, MADH6, MADH7,HsT17432	SMAD family member 6	NM_005585	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila `mothers against decapentaplegic' (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants have been found for this gene.

Downregulated in all human cells samples (including the mock samples) at 23 h post infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	76	44	34	61	63	6	77	57	25
Read_Max	R. aegyptiacus	Transcriptome	27	36	14	17	17	10	20	20	17
Read_Max	R. aegyptiacus	Genome	37	20	23	33	17	9	31	37	41
DESeq	H. sapiens	Genome	1993.03	1167.73	742.64	1592.25	1038.33	97.06	1754.53	941.84	651.23
DESeq	R. aegyptiacus	Transcriptome	158.95	216.12	161.02	135.6	152.12	104.94	244.62	142.28	142.7
DESeq	R. aegyptiacus	Genome	344.62	274.72	468.63	455.23	308.05	214.09	432.94	300.53	349.33

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1993.03	1592.25	1754.53	-0.32	-0.18	0.14
7h	1167.73	1038.33	941.84	-0.17	-0.31	-0.14
23h	742.64	97.06	651.23	-2.94	-0.19	2.75

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1993.03	1167.73	742.64	-0.77	-1.42	-0.65
Ebov	1592.25	1038.33	97.06	-0.62	-4.04	-3.42
Marv	1754.53	941.84	651.23	-0.9	-1.43	-0.53

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	158.95	135.6	244.62	-0.23	0.62	0.85
7h	216.12	152.12	142.28	-0.51	-0.6	-0.1
23h	161.02	104.94	142.7	-0.62	-0.17	0.44

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	158.95	216.12	161.02	0.44	0.02	-0.42
Ebov	135.6	152.12	104.94	0.17	-0.37	-0.54
Marv	244.62	142.28	142.7	-0.78	-0.78	0.0

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material