DAGLA

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
DAGLA	C11orf11, DAGLALPHA, KIAA0659, NSDDR,KIAA0659	diacylglycerol lipase, alpha	NM_006133	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a diacylglycerol lipase (DAGL). The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

The DAGLA gene is low expressed in cell not infected with Ebola and is strongly up-regulated in Ebola infected cell at later stages of infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	28	31	24	36	35	351	44	62	41
Read_Max	R. aegyptiacus	Transcriptome	17	14	13	13	8	17	6	9	14
Read_Max	R. aegyptiacus	Genome	19	13	10	14	8	8	5	13	18
DESeq	H. sapiens	Genome	747.88	772.02	514.29	843.96	682.25	8454.48	893.99	1144.87	1017.67
DESeq	R. aegyptiacus	Transcriptome	115.26	84.51	113.38	87.99	96.27	147.28	77.76	82.79	113.84
DESeq	R. aegyptiacus	Genome	218.29	241.86	315.77	197.5	244.43	275.44	173.18	209.34	297.1

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	747.88	843.96	893.99	0.17	0.26	0.08
7h	772.02	682.25	1144.87	-0.18	0.57	0.75
23h	514.29	8454.48	1017.67	4.04	0.98	-3.05

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	747.88	772.02	514.29	0.05	-0.54	-0.59
Ebov	843.96	682.25	8454.48	-0.31	3.32	3.63
Marv	893.99	1144.87	1017.67	0.36	0.19	-0.17

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	115.26	87.99	77.76	-0.39	-0.57	-0.18
7h	84.51	96.27	82.79	0.19	-0.03	-0.22
23h	113.38	147.28	113.84	0.38	0.01	-0.37

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	115.26	84.51	113.38	-0.45	-0.02	0.42
Ebov	87.99	96.27	147.28	0.13	0.74	0.61
Marv	77.76	82.79	113.84	0.09	0.55	0.46

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material