DUSP10
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| DUSP10 | DUSP10, MKP-5, MKP5,MKP-5 | dual specificity phosphatase 10 | NM_007207 |  |
 |
 |
 |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants.
This gene is up-regulated in Ebola-infected human cells cells after 23 h.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 57 | 40 | 31 | 53 | 44 | 435 | 65 | 78 | 64 |
Read_Max |  | R. aegyptiacus | Transcriptome | 16 | 13 | 19 | 17 | 12 | 26 | 13 | 14 | 22 |
Read_Max |  | R. aegyptiacus | Genome | 19 | 23 | 25 | 15 | 17 | 24 | 12 | 32 | 43 |
DESeq | | H. sapiens | Genome | 715.41 | 439.55 | 273.03 | 613.55 | 325.37 | 4252.74 | 585.22 | 375.1 | 541.41 |
DESeq | | R. aegyptiacus | Transcriptome | 90.05 | 87.23 | 126.82 | 93.48 | 80.94 | 185.78 | 94.44 | 86.93 | 90.22 |
DESeq | | R. aegyptiacus | Genome | 377.27 | 428.96 | 432.92 | 375.24 | 392.88 | 630.51 | 363.22 | 376.65 | 433.23 |