DUSP10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DUSP10 DUSP10, MKP-5, MKP5,MKP-5 dual specificity phosphatase 10 NM_007207 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Dual specificity protein phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the MAP kinase superfamily, which is associated with cellular proliferation and differentiation. Different members of this family of dual specificity phosphatases show distinct substrate specificities for MAP kinases, different tissue distribution and subcellular localization, and different modes of expression induction by extracellular stimuli. This gene product binds to and inactivates p38 and SAPK/JNK. Alternative splicing results in multiple transcript variants.

This gene is up-regulated in Ebola-infected human cells cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome57 40 31 53 44 435 65 78 64
Read_Max
batR. aegyptiacusTranscriptome 16 13 19 17 12 26 13 14 22
Read_Max
bat_genomeR. aegyptiacusGenome 19 23 25 15 17 24 12 32 43
DESeq
humanH. sapiensGenome 715.41 439.55 273.03 613.55 325.37 4252.74 585.22 375.1 541.41
DESeq
batR. aegyptiacusTranscriptome 90.05 87.23 126.82 93.48 80.94 185.78 94.44 86.93 90.22
DESeq
bat_genomeR. aegyptiacusGenome 377.27 428.96 432.92 375.24 392.88 630.51 363.22 376.65 433.23

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 715.41 613.55 585.22 -0.22 -0.29 -0.07
7h 439.55 325.37 375.1 -0.43 -0.23 0.21
23h 273.03 4252.74 541.41 3.96 0.99 -2.97

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 715.41 439.55 273.03 -0.7 -1.39 -0.69
Ebov 613.55 325.37 4252.74 -0.92 2.79 3.71
Marv 585.22 375.1 541.41 -0.64 -0.11 0.53

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 90.05 93.48 94.44 0.05 0.07 0.01
7h 87.23 80.94 86.93 -0.11 -0.0 0.1
23h 126.82 185.78 90.22 0.55 -0.49 -1.04

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 90.05 87.23 126.82 -0.05 0.49 0.54
Ebov 93.48 80.94 185.78 -0.21 0.99 1.2
Marv 94.44 86.93 90.22 -0.12 -0.07 0.05