FHL3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FHL3 SLIM2 four and a half LIM domains 3 NM_004468 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a member of a family of proteinscontaining a four-and-a-half LIM domain, which is a highly conserved doublezinc finger motif. The encoded protein has been shown to interact with thecancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal musclemyogenesis protein MyoD, and the high-affinity IgE beta chain regulatorMZF-1. This protein may be involved in tumor suppression, repression of MyoDexpression, and repression of IgE receptor expression. Two transcriptvariants encoding different isoforms have been found for this gene.

This gene is upregulated in human cells 23 h after Ebola infection and less upregulated in bat cells.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome15 19 10 12 20 156 23 28 16
Read_Max
batR. aegyptiacusTranscriptome 52 90 73 55 58 101 56 60 124
Read_Max
bat_genomeR. aegyptiacusGenome 63 51 50 71 47 40 36 78 116
DESeq
humanH. sapiensGenome 138.0 148.88 80.43 137.88 124.57 1201.12 147.49 201.64 115.17
DESeq
batR. aegyptiacusTranscriptome 313.53 374.97 422.43 300.42 319.67 387.24 313.59 302.57 398.12
DESeq
bat_genomeR. aegyptiacusGenome 495.87 485.55 592.48 532.25 466.54 507.8 463.31 456.74 548.82

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 138.0 137.88 147.49 -0.0 0.1 0.1
7h 148.88 124.57 201.64 -0.26 0.44 0.69
23h 80.43 1201.12 115.17 3.9 0.52 -3.38

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 138.0 148.88 80.43 0.11 -0.78 -0.89
Ebov 137.88 124.57 1201.12 -0.15 3.12 3.27
Marv 147.49 201.64 115.17 0.45 -0.36 -0.81

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 313.53 300.42 313.59 -0.06 0.0 0.06
7h 374.97 319.67 302.57 -0.23 -0.31 -0.08
23h 422.43 387.24 398.12 -0.13 -0.09 0.04

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 313.53 374.97 422.43 0.26 0.43 0.17
Ebov 300.42 319.67 387.24 0.09 0.37 0.28
Marv 313.59 302.57 398.12 -0.05 0.34 0.4