FHL3
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| FHL3 | SLIM2 | four and a half LIM domains 3 | NM_004468 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The protein encoded by this gene is a member of a family of proteinscontaining a four-and-a-half LIM domain, which is a highly conserved doublezinc finger motif. The encoded protein has been shown to interact with thecancer developmental regulators SMAD2, SMAD3, and SMAD4, the skeletal musclemyogenesis protein MyoD, and the high-affinity IgE beta chain regulatorMZF-1. This protein may be involved in tumor suppression, repression of MyoDexpression, and repression of IgE receptor expression. Two transcriptvariants encoding different isoforms have been found for this gene.
This gene is upregulated in human cells 23 h after Ebola infection and less upregulated in bat cells.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 15 | 19 | 10 | 12 | 20 | 156 | 23 | 28 | 16 |
Read_Max |  | R. aegyptiacus | Transcriptome | 52 | 90 | 73 | 55 | 58 | 101 | 56 | 60 | 124 |
Read_Max |  | R. aegyptiacus | Genome | 63 | 51 | 50 | 71 | 47 | 40 | 36 | 78 | 116 |
DESeq | | H. sapiens | Genome | 138.0 | 148.88 | 80.43 | 137.88 | 124.57 | 1201.12 | 147.49 | 201.64 | 115.17 |
DESeq | | R. aegyptiacus | Transcriptome | 313.53 | 374.97 | 422.43 | 300.42 | 319.67 | 387.24 | 313.59 | 302.57 | 398.12 |
DESeq | | R. aegyptiacus | Genome | 495.87 | 485.55 | 592.48 | 532.25 | 466.54 | 507.8 | 463.31 | 456.74 | 548.82 |