NEDD9

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
NEDD9 , CAS-L, CAS2, CASL, CASS2, HEF1,HEF1 neural precursor cell expressed, developmentally down-regulated 9 NM_006403 pdf

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Description

The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.

Strong induction of NEDD9 in Ebola infected human cells cells at 23 h post infection. No induction of the homolog bat cells gene.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome17 14 25 16 16 198 20 20 19
Read_Max
batR. aegyptiacusTranscriptome 448 343 196 182 186 289 256 199 259
Read_Max
bat_genomeR. aegyptiacusGenome 446 193 215 311 155 177 274 277 389
DESeq
humanH. sapiensGenome 273.98 175.4 293.88 255.37 183.1 2746.01 262.41 201.64 276.1
DESeq
batR. aegyptiacusTranscriptome 4237.83 4110.11 3294.26 2339.62 2578.84 4013.51 3905.55 2339.17 3006.5
DESeq
bat_genomeR. aegyptiacusGenome 5503.53 3237.29 4262.27 5599.03 3559.35 5504.91 5638.4 3170.99 4189.35

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 273.98 255.37 262.41 -0.1 -0.06 0.04
7h 175.4 183.1 201.64 0.06 0.2 0.14
23h 293.88 2746.01 276.1 3.22 -0.09 -3.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 273.98 175.4 293.88 -0.64 0.1 0.74
Ebov 255.37 183.1 2746.01 -0.48 3.43 3.91
Marv 262.41 201.64 276.1 -0.38 0.07 0.45

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4237.83 2339.62 3905.55 -0.86 -0.12 0.74
7h 4110.11 2578.84 2339.17 -0.67 -0.81 -0.14
23h 3294.26 4013.51 3006.5 0.28 -0.13 -0.42

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4237.83 4110.11 3294.26 -0.04 -0.36 -0.32
Ebov 2339.62 2578.84 4013.51 0.14 0.78 0.64
Marv 3905.55 2339.17 3006.5 -0.74 -0.38 0.36