WDR66

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
WDR66 CaM-IP4,MGC33630, CaM-IP4 WD repeat domain 66 NM_144668 pdf

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Description

This protein encoded by this gene belongs to the WD repeat-containing family of proteins, which function in the formation of protein-protein complexes in a variety of biological pathways. This family member appears to function in the determination of mean platelet volume (MPV), and polymorphisms in this gene have been associated with variance in MPV. Alternative splicing of this gene results in multiple transcript variants.

Intronic expression in one of the transcripts was detected whereas half of the signal overlaps with an EST signal and shows the same expression behavior like the human cells sample but is generally slightly higher expressed. The other half of the signal remains unchanged during infection but there is no annotation for this signal (e.g.\ ncRNAs).

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome24 25 22 21 25 99 20 19 16
Read_Max
batR. aegyptiacusTranscriptome 7 13 8 4 2 2 4 6 10
Read_Max
bat_genomeR. aegyptiacusGenome 5 7 8 4 5 4 7 9 15
DESeq
humanH. sapiensGenome 61.89 76.47 41.71 72.86 98.55 565.53 72.05 83.33 84.73
DESeq
batR. aegyptiacusTranscriptome 12.76 14.62 21.77 8.33 5.38 3.57 6.56 10.91 19.37
DESeq
bat_genomeR. aegyptiacusGenome 18.05 63.89 109.35 31.6 36.83 39.16 48.35 47.58 63.36

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 61.89 72.86 72.05 0.24 0.22 -0.02
7h 76.47 98.55 83.33 0.37 0.12 -0.24
23h 41.71 565.53 84.73 3.76 1.02 -2.74

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 61.89 76.47 41.71 0.31 -0.57 -0.87
Ebov 72.86 98.55 565.53 0.44 2.96 2.52
Marv 72.05 83.33 84.73 0.21 0.23 0.02

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 12.76 8.33 6.56 -0.62 -0.96 -0.34
7h 14.62 5.38 10.91 -1.44 -0.42 1.02
23h 21.77 3.57 19.37 -2.61 -0.17 2.44

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 12.76 14.62 21.77 0.2 0.77 0.57
Ebov 8.33 5.38 3.57 -0.63 -1.22 -0.59
Marv 6.56 10.91 19.37 0.73 1.56 0.83