NUAK2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
NUAK2	SNARK, FLJ90349	NUAK family, SNF1-like kinase, 2	NM_030952	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens NUAK family, SNF1-like kinase, 2 (NUAK2), mRNA.

This gene shows opposite expression changes in bat cells after Marburg (upregulation) and Ebola (downregulation) infection. In human cells, it is slightly downregulated after 7 h Ebola infection, but highly upregulated in after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	21	22	11	26	14	146	40	28	16
Read_Max	R. aegyptiacus	Transcriptome	121	118	114	96	79	79	98	128	176
Read_Max	R. aegyptiacus	Genome	130	93	92	108	66	43	84	148	166
DESeq	H. sapiens	Genome	407.93	251.89	175.74	360.32	183.91	2082.79	458.9	306.35	302.2
DESeq	R. aegyptiacus	Transcriptome	569.78	661.8	795.0	655.7	567.16	438.56	646.2	707.41	912.45
DESeq	R. aegyptiacus	Genome	1191.97	1180.1	1569.9	1265.95	1147.39	950.34	1196.5	1238.58	1733.79

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	407.93	360.32	458.9	-0.18	0.17	0.35
7h	251.89	183.91	306.35	-0.45	0.28	0.74
23h	175.74	2082.79	302.2	3.57	0.78	-2.78

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	407.93	251.89	175.74	-0.7	-1.21	-0.52
Ebov	360.32	183.91	2082.79	-0.97	2.53	3.5
Marv	458.9	306.35	302.2	-0.58	-0.6	-0.02

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	569.78	655.7	646.2	0.2	0.18	-0.02
7h	661.8	567.16	707.41	-0.22	0.1	0.32
23h	795.0	438.56	912.45	-0.86	0.2	1.06

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	569.78	661.8	795.0	0.22	0.48	0.26
Ebov	655.7	567.16	438.56	-0.21	-0.58	-0.37
Marv	646.2	707.41	912.45	0.13	0.5	0.37

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material