PCDHB8

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PCDHB8 PCDH-BETA8, PCDH3I,PCDH-BETA8 protocadherin beta 8 NM_019120 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins. Their specific functions are unknown but they most likely play a critical role in the establishment and function of specific cell-cell neural connections.

Gene expressed uniformely in bat cells and human cells, but downregulation in human cells after 23 h Ebola virus infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome109 121 106 98 108 18 102 128 117
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 34 31 23 36 22 11 21 24 28
DESeq
humanH. sapiensGenome 666.7 692.47 718.81 699.1 539.99 61.53 537.85 611.7 620.79
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 233.75 228.17 244.36 201.45 198.67 262.39 218.16 208.54 220.9

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 666.7 699.1 537.85 0.07 -0.31 -0.38
7h 692.47 539.99 611.7 -0.36 -0.18 0.18
23h 718.81 61.53 620.79 -3.55 -0.21 3.33

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 666.7 692.47 718.81 0.05 0.11 0.05
Ebov 699.1 539.99 61.53 -0.37 -3.51 -3.13
Marv 537.85 611.7 620.79 0.19 0.21 0.02

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA