ST6GAL1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ST6GAL1 SIAT1, B-Cell Antigen CD75 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1 NM_173216 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Three transcript variants encoding two different isoforms have been described.

The gene ST6GAL1 is well expressed throughout human cells datasets, except for cells after 23 h Ebola infection, where almost no expression is detectable.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome824 853 897 680 903 110 878 1147 662
Read_Max
batR. aegyptiacusTranscriptome 54 27 26 27 30 25 23 42 26
Read_Max
bat_genomeR. aegyptiacusGenome 67 48 34 41 32 20 28 69 54
DESeq
humanH. sapiensGenome 14795.58 14097.68 16164.19 14312.01 13313.07 1491.94 13749.43 14061.57 13422.12
DESeq
batR. aegyptiacusTranscriptome 227.0 181.63 175.68 201.53 220.02 169.1 199.01 206.73 191.69
DESeq
bat_genomeR. aegyptiacusGenome 824.16 789.47 794.43 749.5 795.8 791.08 739.94 834.18 785.13

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 14795.58 14312.01 13749.43 -0.05 -0.11 -0.06
7h 14097.68 13313.07 14061.57 -0.08 -0.0 0.08
23h 16164.19 1491.94 13422.12 -3.44 -0.27 3.17

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 14795.58 14097.68 16164.19 -0.07 0.13 0.2
Ebov 14312.01 13313.07 1491.94 -0.1 -3.26 -3.16
Marv 13749.43 14061.57 13422.12 0.03 -0.03 -0.07

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 227.0 201.53 199.01 -0.17 -0.19 -0.02
7h 181.63 220.02 206.73 0.28 0.19 -0.09
23h 175.68 169.1 191.69 -0.06 0.13 0.18

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 227.0 181.63 175.68 -0.32 -0.37 -0.05
Ebov 201.53 220.02 169.1 0.13 -0.25 -0.38
Marv 199.01 206.73 191.69 0.05 -0.05 -0.11