FGF18

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FGF18 FGF-18, ZFGF5,FGF-18 fibroblast growth factor 18 NM_033649, NM_003862 pdf NONE NONE NONE

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Description

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. The gene is not expressed in human, neither is the bat homolog.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome5 5 5 4 5 8 7 6 3
Read_Max
batR. aegyptiacusTranscriptome NA 1 NA NA NA 2 2 2 2
Read_Max
bat_genomeR. aegyptiacusGenome 1 1 2 2 2 0 2 4 5
DESeq
humanH. sapiensGenome 46.67 39.76 65.53 31.8 50.59 269.45 32.58 44.96 27.1
DESeq
batR. aegyptiacusTranscriptome 1.0 1.91 1.0 1.0 1.0 3.57 3.22 3.48 3.62
DESeq
bat_genomeR. aegyptiacusGenome 2.58 1.83 5.58 6.91 5.58 0.0 4.5 6.34 17.12

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 46.67 31.8 32.58 -0.55 -0.52 0.03
7h 39.76 50.59 44.96 0.35 0.18 -0.17
23h 65.53 269.45 27.1 2.04 -1.27 -3.31

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 46.67 39.76 65.53 -0.23 0.49 0.72
Ebov 31.8 50.59 269.45 0.67 3.08 2.41
Marv 32.58 44.96 27.1 0.46 -0.27 -0.73

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1.0 1.0 3.22 0.0 1.69 1.69
7h 1.91 1.0 3.48 -0.93 0.87 1.8
23h 1.0 3.57 3.62 1.84 1.86 0.02

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1.0 1.91 1.0 0.93 0.0 -0.93
Ebov 1.0 1.0 3.57 0.0 1.84 1.84
Marv 3.22 3.48 3.62 0.11 0.17 0.06