ABCB11

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ABCB11 ABC16, BSEP, PFIC-2, PFIC2, PGY4, SPGP ATP-binding cassette, sub-family B (MDR/TAP), member 11 NM_003742 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.

This gene is very low in expression in all investigated cell lines.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome11 7 7 10 7 3 10 11 9
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 0 0 0 0 0 0 0 0 0
DESeq
humanH. sapiensGenome 108.57 94.83 82.41 112.79 87.99 12.84 122.05 116.91 120.61
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 108.57 112.79 122.05 0.06 0.17 0.11
7h 94.83 87.99 116.91 -0.11 0.3 0.41
23h 82.41 12.84 120.61 -2.68 0.55 3.23

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 108.57 94.83 82.41 -0.2 -0.4 -0.2
Ebov 112.79 87.99 12.84 -0.36 -3.13 -2.78
Marv 122.05 116.91 120.61 -0.06 -0.02 0.04

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA