CDKN1A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
CDKN1A CAP20, CDKN1, CDN1A_HUMAN, CIP1, MDA6, NM_078467, NP_510867, P38936, PIC1, Q14010, Q9BUT4, SDI1, WAF1,P21, CAP20, p21CIP1, p21Cip1/Waf1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) NM_078467 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens cyclin-dependent kinase inhibitor 1A (p21, Cip1) (CDKN1A), transcript variant 2 gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

In RAE no homolog gene was found, but in hg19 (MOCK equal expressed over time) the expression is upregulated during ebola infection and even 3 fold upregulated during marburg infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome6 7 6 10 4 26 13 7 34
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 1 2 2 2 1 1 2 3 2
DESeq
humanH. sapiensGenome 33.47 43.83 37.73 46.63 22.95 182.6 38.72 48.16 366.35
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 1.72 1.83 6.69 5.92 2.23 2.61 3.37 1.59 1.71

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 33.47 46.63 38.72 0.48 0.21 -0.27
7h 43.83 22.95 48.16 -0.93 0.14 1.07
23h 37.73 182.6 366.35 2.27 3.28 1.0

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 33.47 43.83 37.73 0.39 0.17 -0.22
Ebov 46.63 22.95 182.6 -1.02 1.97 2.99
Marv 38.72 48.16 366.35 0.31 3.24 2.93

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA