KDM6B

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
KDM6B	KIAA0346	lysine (K)-specific demethylase 6B	XM_043272	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Histone demethylase that specifically demethylates `Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 `Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation.

The gene is differentially upregulated in human cells, but not in bat cells after infection with Ebola. The expression increases from 3 h to 7 h and from 7 h to 23 h after infection. In contrast, infection with Marburg virus does not change the expression of KDM6B.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	57	58	67	47	83	715	75	88	61
Read_Max	R. aegyptiacus	Transcriptome	30	29	75	43	47	88	22	53	69
Read_Max	R. aegyptiacus	Genome	41	43	62	26	42	49	19	62	81
DESeq	H. sapiens	Genome	1437.94	1461.46	1372.09	1198.72	1375.7	11650.86	1194.0	1642.07	1657.03
DESeq	R. aegyptiacus	Transcriptome	585.74	584.64	1729.47	892.86	842.03	1365.02	519.38	866.87	1201.1
DESeq	R. aegyptiacus	Genome	805.25	1076.06	2083.16	789.0	1056.98	1708.78	655.6	1053.03	1531.73

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1437.94	1198.72	1194.0	-0.26	-0.27	-0.01
7h	1461.46	1375.7	1642.07	-0.09	0.17	0.26
23h	1372.09	11650.86	1657.03	3.09	0.27	-2.81

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1437.94	1461.46	1372.09	0.02	-0.07	-0.09
Ebov	1198.72	1375.7	11650.86	0.2	3.28	3.08
Marv	1194.0	1642.07	1657.03	0.46	0.47	0.01

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	585.74	892.86	519.38	0.61	-0.17	-0.78
7h	584.64	842.03	866.87	0.53	0.57	0.04
23h	1729.47	1365.02	1201.1	-0.34	-0.53	-0.18

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	585.74	584.64	1729.47	-0.0	1.56	1.56
Ebov	892.86	842.03	1365.02	-0.08	0.61	0.7
Marv	519.38	866.87	1201.1	0.74	1.21	0.47

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material