SYNGAP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SYNGAP1 upstream region: XLOC_015180, ,SYNGAP, RASA5, KIAA1938 synaptic Ras GTPase activating protein 1 XM_166407 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene is a major component of the postsynaptic density (PSD), a group of proteins found associated with NMDA receptors at synapses. The encoded protein is phosphorylated by calmodulin-dependent protein kinase II and dephosphorylated by NMDA receptor activation. Defects in this gene are a cause of mental retardation autosomal dominant type 5 (MRD5).

The gene is not present in human cells cells except after 23 h of Ebola infection and on the other hand is moderately expressed in all bat cells samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome7 6 9 8 10 58 11 9 10
Read_Max
batR. aegyptiacusTranscriptome 26 35 47 49 29 43 33 37 67
Read_Max
bat_genomeR. aegyptiacusGenome 40 68 40 37 38 30 31 55 79
DESeq
humanH. sapiensGenome 152.2 171.32 200.56 153.85 183.1 1428.78 151.88 200.04 215.21
DESeq
batR. aegyptiacusTranscriptome 241.28 238.81 457.85 360.86 286.82 396.22 216.81 313.31 446.23
DESeq
bat_genomeR. aegyptiacusGenome 657.43 1059.63 1299.88 744.56 945.37 1082.18 564.52 945.98 1139.59

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 152.2 153.85 151.88 0.02 -0.0 -0.02
7h 171.32 183.1 200.04 0.1 0.22 0.13
23h 200.56 1428.78 215.21 2.83 0.1 -2.73

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 152.2 171.32 200.56 0.17 0.4 0.23
Ebov 153.85 183.1 1428.78 0.25 3.22 2.96
Marv 151.88 200.04 215.21 0.4 0.5 0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 241.28 360.86 216.81 0.58 -0.15 -0.74
7h 238.81 286.82 313.31 0.26 0.39 0.13
23h 457.85 396.22 446.23 -0.21 -0.04 0.17

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 241.28 238.81 457.85 -0.01 0.92 0.94
Ebov 360.86 286.82 396.22 -0.33 0.13 0.47
Marv 216.81 313.31 446.23 0.53 1.04 0.51