ACADSB

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
ACADSB SBCAD, ACAD7 acyl-CoA dehydrogenase, short/branched chain NM_001609 pdf NONE

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Description

Short/branched chain acyl-CoA dehydrogenase(ACADSB) is a member of the acyl-CoA dehydrogenase family of enzymes that catalyze the dehydrogenation of acyl-CoA derivatives in the metabolism of fatty acids or branch chained amino acids. Substrate specificity is the primary characteristic used to define members of this gene family. The ACADSB gene product has the greatest activity towards the short branched chain acyl-CoA derivative, (S)-2-methylbutyryl-CoA, but also reacts significantly with other 2-methyl branched chain substrates and with short straight chain acyl-CoAs. The cDNA encodes for a mitochondrial precursor protein which is cleaved upon mitochondrial import and predicted to yield a mature peptide of approximately 43.7-KDa. [provided by RefSeq, Jul 2008]. Sequence Note: The 3' UTR extension represented by the RefSeq transcript record was derived from genomic sequence data to optimize consistency to the reference genome assembly. The extent of the UTR extension and the location of the polyA site was based on transcript alignments.

The gene, whose homolog was not expressed in bat cells, shows in human cells for Ebola and Marburg infection a huge upregulation for the 7 h sample and is downregulated afterwards, for Ebola nearly turned off. All samples show a slight expression of the first intron with length of nearly 25\,000\,nt.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome704 794 719 893 1121 86 904 1165 371
Read_Max
batR. aegyptiacusTranscriptome 2 NA 4 5 NA 2 1 2 1
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 10839.94 10813.69 10566.64 12118.48 12306.64 1332.71 11319.57 10210.3 5965.1
DESeq
batR. aegyptiacusTranscriptome 4.36 1.0 10.77 6.49 1.0 4.85 3.22 2.65 1.87
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10839.94 12118.48 11319.57 0.16 0.06 -0.1
7h 10813.69 12306.64 10210.3 0.19 -0.08 -0.27
23h 10566.64 1332.71 5965.1 -2.99 -0.82 2.16

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10839.94 10813.69 10566.64 -0.0 -0.04 -0.03
Ebov 12118.48 12306.64 1332.71 0.02 -3.18 -3.21
Marv 11319.57 10210.3 5965.1 -0.15 -0.92 -0.78

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4.36 6.49 3.22 0.57 -0.44 -1.01
7h 1.0 1.0 2.65 0.0 1.41 1.41
23h 10.77 4.85 1.87 -1.15 -2.53 -1.37

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4.36 1.0 10.77 -2.12 1.3 3.43
Ebov 6.49 1.0 4.85 -2.7 -0.42 2.28
Marv 3.22 2.65 1.87 -0.28 -0.78 -0.5