HSPA1A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HSPA1A B4E3B6, HSP71_HUMAN, HSPA1, HSPA1B,HSP70-1 heat shock 70kDa protein 1A pdf

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Description

This intronless gene HSPA1A encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins.

This gene is highly differential expressed in all samples. In the Ebola probes a constant upregulation was observed and the 23 h probe shows the highest expression of this gene ($\sim$3,500 reads, 10x higher than in 3 h probe). For the wildtype and Marburg virus infected cells, first an upregulation and than a downregulation took place.

The gene was also expressed in the bat cells and the highest expression was detected in the 23 h Marburg probe.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome430 1458 498 349 2029 3758 466 2126 609
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 102 91 62 79 73 159 62 155 106
DESeq
humanH. sapiensGenome 1004.62 3738.83 1313.51 858.79 3563.35 7562.29 868.56 4091.28 1842.97
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 263.83 345.91 321.34 245.88 380.6 1186.62 310.37 444.05 306.52

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1004.62 858.79 868.56 -0.23 -0.21 0.02
7h 3738.83 3563.35 4091.28 -0.07 0.13 0.2
23h 1313.51 7562.29 1842.97 2.53 0.49 -2.04

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1004.62 3738.83 1313.51 1.9 0.39 -1.51
Ebov 858.79 3563.35 7562.29 2.05 3.14 1.09
Marv 868.56 4091.28 1842.97 2.24 1.09 -1.15

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA