GPAM

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
GPAM KIAA1560, MGC26846, GPAT1 glycerol-3-phosphate acyltransferase, mitochondrial NM_020918 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a mitochondrial enzyme which prefers saturated fatty acids as its substrate for the synthesis of glycerolipids. This metabolic pathway's first step is catalyzed by the encoded enzyme. Two forms for this enzyme exist, one in the mitochondria and one in the endoplasmic reticulum. Two alternatively spliced transcript variants have been described for this gene.

This gene was expressed in all probes. For the 23 h probes, a slight upregulation was observed in the human cells wildtype probe. All other 23 h probes (both human cells and bat cells) showed a slight downregulation. However, a huge downregulation (almost 8x) was observed for the 23 h infected Ebola probe in human cells.

We also found two alternatively spliced exons in the 3'UTR that are not part of the RefSeq-Annotation.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome382 337 463 334 570 75 355 394 253
Read_Max
batR. aegyptiacusTranscriptome 119 122 74 123 112 103 112 134 84
Read_Max
bat_genomeR. aegyptiacusGenome 123 125 57 123 85 55 95 155 93
DESeq
humanH. sapiensGenome 8091.9 7260.46 8294.06 7491.87 8258.14 1036.63 6544.95 6619.62 5536.68
DESeq
batR. aegyptiacusTranscriptome 1335.14 1209.14 1011.21 1479.8 1441.04 955.69 1430.44 1420.43 821.48
DESeq
bat_genomeR. aegyptiacusGenome 2204.34 2336.47 1490.68 2118.15 2266.87 1522.11 2282.8 2187.74 1328.81

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8091.9 7491.87 6544.95 -0.11 -0.31 -0.19
7h 7260.46 8258.14 6619.62 0.19 -0.13 -0.32
23h 8294.06 1036.63 5536.68 -3.0 -0.58 2.42

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8091.9 7260.46 8294.06 -0.16 0.04 0.19
Ebov 7491.87 8258.14 1036.63 0.14 -2.85 -2.99
Marv 6544.95 6619.62 5536.68 0.02 -0.24 -0.26

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1335.14 1479.8 1430.44 0.15 0.1 -0.05
7h 1209.14 1441.04 1420.43 0.25 0.23 -0.02
23h 1011.21 955.69 821.48 -0.08 -0.3 -0.22

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1335.14 1209.14 1011.21 -0.14 -0.4 -0.26
Ebov 1479.8 1441.04 955.69 -0.04 -0.63 -0.59
Marv 1430.44 1420.43 821.48 -0.01 -0.8 -0.79