DUSP4

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
DUSP4 G5E930, G5E930_HUMAN, hCG_1639778, NM_057158, NP_476499,HVH2, MKP-2, TYP dual specificity phosphatase 4 NM_001394 pdf

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Description

Homo sapiens dual specificity phosphatase 4 (DUSP4), transcript variant 2 protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported.

This gene shows a minor expression in HG19, which is upregulated during marburg infection and highly, up to 5 fold, upregulated in the ebola infected samples. On the other hand, the homolog sequence in the RAE transcripts assembly shows a high expression level, which goes slightly down for RAE MOCK and Ebola after 7h. It increases for marburg and after 23h a 2 fold upregulation could be observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome25 26 28 22 32 175 36 48 64
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 202 208 144 157 143 142 118 213 443
DESeq
humanH. sapiensGenome 525.64 544.59 554.0 525.71 472.51 3506.62 589.6 707.63 1646.16
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 2078.01 2355.64 2376.61 2285.04 2523.58 2661.73 2213.08 2133.02 4057.49

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 525.64 525.71 589.6 0.0 0.17 0.17
7h 544.59 472.51 707.63 -0.2 0.38 0.58
23h 554.0 3506.62 1646.16 2.66 1.57 -1.09

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 525.64 544.59 554.0 0.05 0.08 0.02
Ebov 525.71 472.51 3506.62 -0.15 2.74 2.89
Marv 589.6 707.63 1646.16 0.26 1.48 1.22

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA