ZFP36

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ZFP36	B2RA54, G0S24, NM_003407, NP_003398, P26651, RNF162A, TIS11A, TTP, TTP_HUMAN, uc002olh.1,RNF162A, TIS11, NUP475	ZFP36 ring finger protein		pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Homo sapiens ZFP36 ring finger protein (ZFP36) is involved in post-transcriptional regulation of AU-rich element (ARE)-containing mRNAs. Acts by specifically binding ARE-containing mRNAs and promoting their degradation. Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1. Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF). Plays a key role in the post-transcriptional regulation of tumor necrosis factor (TNF).

This gene is low and equal expressed in all RAE samples with different read mapping profiles/distributions. For HG19 ebola samples, it shows a high (6 fold) increase of transcripts, whereas the MOCK ones slightly decrease and during marburg infection the gene is first upregulated until 7h and afterwords downregulated, as seen in the 23h sample.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	31	25	19	17	31	133	29	40	29
Read_Max	R. aegyptiacus	Transcriptome	17	15	17	13	15	25	15	9	22
Read_Max	R. aegyptiacus	Genome	16	14	12	15	13	15	4	14	23
DESeq	H. sapiens	Genome	234.4	179.48	134.04	149.29	131.89	968.2	193.99	243.2	264.14
DESeq	R. aegyptiacus	Transcriptome	47.21	53.65	82.84	66.01	74.37	103.65	41.05	34.87	101.59
DESeq	R. aegyptiacus	Genome	64.45	84.88	108.23	61.22	92.64	142.29	42.73	64.23	144.7

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	234.4	149.29	193.99	-0.65	-0.27	0.38
7h	179.48	131.89	243.2	-0.44	0.44	0.88
23h	134.04	968.2	264.14	2.85	0.98	-1.87

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	234.4	179.48	134.04	-0.39	-0.81	-0.42
Ebov	149.29	131.89	968.2	-0.18	2.7	2.88
Marv	193.99	243.2	264.14	0.33	0.45	0.12

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	47.21	66.01	41.05	0.48	-0.2	-0.69
7h	53.65	74.37	34.87	0.47	-0.62	-1.09
23h	82.84	103.65	101.59	0.32	0.29	-0.03

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	47.21	53.65	82.84	0.18	0.81	0.63
Ebov	66.01	74.37	103.65	0.17	0.65	0.48
Marv	41.05	34.87	101.59	-0.24	1.31	1.54

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material