MAP1B

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MAP1B FUTSCH, MAP5, PPP1R102,MAP5 microtubule-associated protein 1B NM_005909 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

microtubule-associated protein 1B is involved in axon extension, negative regulation of intracellular transport and dendrite development. Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

It does not present a particularly interesting differential expression pattern in the samples analyzed, except for the slight upregulation after 3 hours of infection with Ebola in humans and the slight downregulation after 23 hours of infection with Marburg virus in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome18 24 25 17 46 50 22 30 100
Read_Max
batR. aegyptiacusTranscriptome 476 282 462 730 646 437 524 691 590
Read_Max
bat_genomeR. aegyptiacusGenome 512 679 364 266 495 242 430 791 635
DESeq
humanH. sapiensGenome 655.54 764.88 670.16 555.37 824.52 977.41 550.13 812.34 4005.7
DESeq
batR. aegyptiacusTranscriptome 10394.38 7842.53 10073.79 11712.4 12639.43 9744.2 11850.35 9480.92 11516.54
DESeq
bat_genomeR. aegyptiacusGenome 11563.09 12533.9 10140.19 9305.06 14088.96 10936.72 13522.5 10451.03 12470.43

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 655.54 555.37 550.13 -0.24 -0.25 -0.01
7h 764.88 824.52 812.34 0.11 0.09 -0.02
23h 670.16 977.41 4005.7 0.54 2.58 2.04

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 655.54 764.88 670.16 0.22 0.03 -0.19
Ebov 555.37 824.52 977.41 0.57 0.82 0.25
Marv 550.13 812.34 4005.7 0.56 2.86 2.3

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 10394.38 11712.4 11850.35 0.17 0.19 0.02
7h 7842.53 12639.43 9480.92 0.69 0.27 -0.41
23h 10073.79 9744.2 11516.54 -0.05 0.19 0.24

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 10394.38 7842.53 10073.79 -0.41 -0.05 0.36
Ebov 11712.4 12639.43 9744.2 0.11 -0.27 -0.38
Marv 11850.35 9480.92 11516.54 -0.32 -0.04 0.28