MAP1B

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAP1B	FUTSCH, MAP5, PPP1R102,MAP5	microtubule-associated protein 1B	NM_005909	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

microtubule-associated protein 1B is involved in axon extension, negative regulation of intracellular transport and dendrite development. Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B may play a role in the cytoskeletal changes that accompany neurite extension. Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.

It does not present a particularly interesting differential expression pattern in the samples analyzed, except for the slight upregulation after 3 hours of infection with Ebola in humans and the slight downregulation after 23 hours of infection with Marburg virus in humans.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	18	24	25	17	46	50	22	30	100
Read_Max	R. aegyptiacus	Transcriptome	476	282	462	730	646	437	524	691	590
Read_Max	R. aegyptiacus	Genome	512	679	364	266	495	242	430	791	635
DESeq	H. sapiens	Genome	655.54	764.88	670.16	555.37	824.52	977.41	550.13	812.34	4005.7
DESeq	R. aegyptiacus	Transcriptome	10394.38	7842.53	10073.79	11712.4	12639.43	9744.2	11850.35	9480.92	11516.54
DESeq	R. aegyptiacus	Genome	11563.09	12533.9	10140.19	9305.06	14088.96	10936.72	13522.5	10451.03	12470.43

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	655.54	555.37	550.13	-0.24	-0.25	-0.01
7h	764.88	824.52	812.34	0.11	0.09	-0.02
23h	670.16	977.41	4005.7	0.54	2.58	2.04

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	655.54	764.88	670.16	0.22	0.03	-0.19
Ebov	555.37	824.52	977.41	0.57	0.82	0.25
Marv	550.13	812.34	4005.7	0.56	2.86	2.3

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	10394.38	11712.4	11850.35	0.17	0.19	0.02
7h	7842.53	12639.43	9480.92	0.69	0.27	-0.41
23h	10073.79	9744.2	11516.54	-0.05	0.19	0.24

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	10394.38	7842.53	10073.79	-0.41	-0.05	0.36
Ebov	11712.4	12639.43	9744.2	0.11	-0.27	-0.38
Marv	11850.35	9480.92	11516.54	-0.32	-0.04	0.28

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material