SKP2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SKP2 FBL1, FBXL1, FLB1, p45,FBXL1, FBL1 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase NM_005983 pdf

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Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). Gene is highly expressed in human, but strongly (7 fold) downregulated in EBOV 23h and 4 fold in MARV 23h. Expression in bat is much lower and also more stable, with a slight downregulation at 7h MARV and EBOV.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome1621 1280 818 1176 1233 159 1401 1536 402
Read_Max
batR. aegyptiacusTranscriptome 244 245 86 215 128 118 180 192 141
Read_Max
bat_genomeR. aegyptiacusGenome 264 207 77 222 112 68 150 217 154
DESeq
humanH. sapiensGenome 16747.01 14700.43 11665.7 13774.75 12545.64 1930.14 13554.69 12396.53 5668.25
DESeq
batR. aegyptiacusTranscriptome 2437.41 2205.78 1284.84 1996.24 1695.1 1408.65 2532.84 1904.58 1482.76
DESeq
bat_genomeR. aegyptiacusGenome 2911.61 2351.08 1466.13 2748.17 2103.91 1597.82 2963.14 2342.36 1756.91

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 16747.01 13774.75 13554.69 -0.28 -0.31 -0.02
7h 14700.43 12545.64 12396.53 -0.23 -0.25 -0.02
23h 11665.7 1930.14 5668.25 -2.6 -1.04 1.55

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 16747.01 14700.43 11665.7 -0.19 -0.52 -0.33
Ebov 13774.75 12545.64 1930.14 -0.13 -2.84 -2.7
Marv 13554.69 12396.53 5668.25 -0.13 -1.26 -1.13

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2437.41 1996.24 2532.84 -0.29 0.06 0.34
7h 2205.78 1695.1 1904.58 -0.38 -0.21 0.17
23h 1284.84 1408.65 1482.76 0.13 0.21 0.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2437.41 2205.78 1284.84 -0.14 -0.92 -0.78
Ebov 1996.24 1695.1 1408.65 -0.24 -0.5 -0.27
Marv 2532.84 1904.58 1482.76 -0.41 -0.77 -0.36