Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

Back to supplement page

SKP2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (humangenome)	Sashimi-img (humangenome)	UCSC-img (humangenome)	IGV-img (batgenome)
SKP2	FBL1, FBXL1, FLB1, p45,FBXL1, FBL1	S-phase kinase-associated protein 2, E3 ubiquitin protein ligase	NM_005983	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). Gene is highly expressed in human, but strongly (7 fold) downregulated in EBOV 23h and 4 fold in MARV 23h. Expression in bat is much lower and also more stable, with a slight downregulation at 7h MARV and EBOV.

Show legend