MBNL2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MBNL2 MBLL, MBLL39, PRO2032 muscleblind-like splicing regulator 2 NM_144778 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the muscleblind protein family which was initially described in Drosophila melanogaster. This gene encodes a C3H-type zinc finger protein that modulates alternative splicing of pre-mRNAs. Muscleblind proteins bind specifically to expanded dsCUG RNA but not to normal size CUG repeats and may thereby play a role in the pathophysiology of myotonic dystrophy. Expressed in human as well as rae. Highly upregulated in EBOV 23h.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome72 71 69 49 91 327 60 81 106
Read_Max
batR. aegyptiacusTranscriptome 157 119 71 98 65 107 100 82 78
Read_Max
bat_genomeR. aegyptiacusGenome 185 167 83 122 80 86 108 173 131
DESeq
humanH. sapiensGenome 1223.82 1179.97 1003.75 890.73 1020.44 6096.35 911.54 945.03 1582.0
DESeq
batR. aegyptiacusTranscriptome 793.25 647.28 454.19 511.03 384.28 530.95 652.87 384.36 306.27
DESeq
bat_genomeR. aegyptiacusGenome 2402.85 1949.49 1728.34 2025.33 1703.22 2072.99 2291.8 1669.15 1315.97

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1223.82 890.73 911.54 -0.46 -0.43 0.03
7h 1179.97 1020.44 945.03 -0.21 -0.32 -0.11
23h 1003.75 6096.35 1582.0 2.6 0.66 -1.95

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1223.82 1179.97 1003.75 -0.05 -0.29 -0.23
Ebov 890.73 1020.44 6096.35 0.2 2.77 2.58
Marv 911.54 945.03 1582.0 0.05 0.8 0.74

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 793.25 511.03 652.87 -0.63 -0.28 0.35
7h 647.28 384.28 384.36 -0.75 -0.75 0.0
23h 454.19 530.95 306.27 0.23 -0.57 -0.79

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 793.25 647.28 454.19 -0.29 -0.8 -0.51
Ebov 511.03 384.28 530.95 -0.41 0.06 0.47
Marv 652.87 384.36 306.27 -0.76 -1.09 -0.33