MAP3K9

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
MAP3K9	MAP3K9, MEKK9, MLK1, PRKE1,PRKE1	mitogen-activated protein kinase kinase kinase 9		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment.

This gene is highly upregulated in Ebola infected human cells cells 23 h after infection. Marburg infection shows no similar effect.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	32	44	42	39	40	234	42	46	49
Read_Max	R. aegyptiacus	Transcriptome	12	14	12	14	13	14	16	17	20
Read_Max	R. aegyptiacus	Genome	13	15	10	12	10	8	11	16	20
DESeq	H. sapiens	Genome	781.37	866.87	792.28	850.81	887.12	5310.75	824.7	791.56	1102.48
DESeq	R. aegyptiacus	Transcriptome	134.58	126.26	145.14	142.93	156.5	166.53	103.34	140.63	182.94
DESeq	R. aegyptiacus	Genome	322.27	382.41	369.32	303.16	399.58	451.67	281.13	362.38	499.16

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	781.37	850.81	824.7	0.12	0.08	-0.04
7h	866.87	887.12	791.56	0.03	-0.13	-0.16
23h	792.28	5310.75	1102.48	2.74	0.48	-2.27

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	781.37	866.87	792.28	0.15	0.02	-0.13
Ebov	850.81	887.12	5310.75	0.06	2.64	2.58
Marv	824.7	791.56	1102.48	-0.06	0.42	0.48

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	134.58	142.93	103.34	0.09	-0.38	-0.47
7h	126.26	156.5	140.63	0.31	0.16	-0.15
23h	145.14	166.53	182.94	0.2	0.33	0.14

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	134.58	126.26	145.14	-0.09	0.11	0.2
Ebov	142.93	156.5	166.53	0.13	0.22	0.09
Marv	103.34	140.63	182.94	0.44	0.82	0.38

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material