MGAT4A

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MGAT4A GnT-4a,GnT-Iva, GnT-4a mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A NM_012214 pdf

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Description

Homo sapiens mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A (MGAT4A). This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome186 211 257 164 279 60 190 271 124
Read_Max
batR. aegyptiacusTranscriptome 51 37 22 40 39 68 45 47 47
Read_Max
bat_genomeR. aegyptiacusGenome 65 72 33 50 64 56 47 91 58
DESeq
humanH. sapiensGenome 5325.59 5512.39 7916.79 4340.16 5885.95 1185.33 4033.51 4891.43 4362.35
DESeq
batR. aegyptiacusTranscriptome 287.49 246.08 206.22 282.11 328.43 457.81 324.71 304.22 301.03
DESeq
bat_genomeR. aegyptiacusGenome 598.14 664.43 514.37 510.53 723.25 1053.47 723.07 664.49 618.17

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5325.59 4340.16 4033.51 -0.3 -0.4 -0.11
7h 5512.39 5885.95 4891.43 0.09 -0.17 -0.27
23h 7916.79 1185.33 4362.35 -2.74 -0.86 1.88

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5325.59 5512.39 7916.79 0.05 0.57 0.52
Ebov 4340.16 5885.95 1185.33 0.44 -1.87 -2.31
Marv 4033.51 4891.43 4362.35 0.28 0.11 -0.17

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 287.49 282.11 324.71 -0.03 0.18 0.2
7h 246.08 328.43 304.22 0.42 0.31 -0.11
23h 206.22 457.81 301.03 1.15 0.55 -0.6

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 287.49 246.08 206.22 -0.22 -0.48 -0.25
Ebov 282.11 328.43 457.81 0.22 0.7 0.48
Marv 324.71 304.22 301.03 -0.09 -0.11 -0.02