SHC2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SHC2	SCK, SHCB, SLI,SLI, SCK	SHC (Src homology 2 domain containing) transforming protein 2		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The SHC (Src homology 2 domain containing) transforming protein 2 is involved in the ErbB, Ras, Chemokine and VEGF signaling pathways, focal adhesion, natural killer cell mediated cytotoxicity. neurotrophin, insulin, estrogen and prolactin signaling pathway, alcoholism, bacterial invasion of epithelial cells, glioma and chronic myeloid leukemia. It seems to be upregulated after 23 hours of Ebola infection in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	25	25	25	27	42	270	37	32	33
Read_Max	R. aegyptiacus	Transcriptome	17	18	22	16	15	29	29	16	32
Read_Max	R. aegyptiacus	Genome	24	20	22	19	19	18	22	28	43
DESeq	H. sapiens	Genome	464.76	459.94	490.46	532.56	456.25	2947.35	491.36	511.78	689.29
DESeq	R. aegyptiacus	Transcriptome	90.05	78.15	135.37	90.74	95.18	138.3	142.28	88.58	190.81
DESeq	R. aegyptiacus	Genome	213.13	293.88	418.42	202.43	255.59	368.13	251.9	271.98	509.43

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	464.76	532.56	491.36	0.2	0.08	-0.12
7h	459.94	456.25	511.78	-0.01	0.15	0.17
23h	490.46	2947.35	689.29	2.59	0.49	-2.1

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	464.76	459.94	490.46	-0.02	0.08	0.09
Ebov	532.56	456.25	2947.35	-0.22	2.47	2.69
Marv	491.36	511.78	689.29	0.06	0.49	0.43

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	90.05	90.74	142.28	0.01	0.66	0.65
7h	78.15	95.18	88.58	0.28	0.18	-0.1
23h	135.37	138.3	190.81	0.03	0.5	0.46

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	90.05	78.15	135.37	-0.2	0.59	0.79
Ebov	90.74	95.18	138.3	0.07	0.61	0.54
Marv	142.28	88.58	190.81	-0.68	0.42	1.11

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material