MEF2D

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MEF2D myocyte enhancer factor 2D NM_005920 pdf

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Description

MEF2D is a member of the myocyte-specific enhancer factor 2 (MEF2) family of transcription factors. Members of this family are involved in control of muscle and neuronal cell differentiation and development, and are regulated by class II histone deacetylases. Fusions of the encoded protein with Deleted in Azoospermia-Associated Protein 1 (DAZAP1) due to a translocation have been found in an acute lymphoblastic leukemia cell line, suggesting a role in leukemogenesis. The encoded protein may also be involved in Parkinson disease and myotonic dystrophy. Alternative splicing results in multiple transcript variants.

For all probes slight differential expression was observed. However it was most significant for 23 h Ebola infected human cells cells as here a 4x upregulation was observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome69 109 60 94 110 414 109 119 61
Read_Max
batR. aegyptiacusTranscriptome 69 71 79 74 45 148 45 66 93
Read_Max
bat_genomeR. aegyptiacusGenome 73 77 65 58 36 79 37 64 98
DESeq
humanH. sapiensGenome 1398.36 1451.26 1227.14 1369.82 1170.02 7267.52 1375.58 1386.27 1492.84
DESeq
batR. aegyptiacusTranscriptome 353.02 305.98 551.91 330.64 362.38 596.4 304.69 364.53 457.6
DESeq
bat_genomeR. aegyptiacusGenome 1068.22 1138.12 1766.28 1016.12 1148.5 1958.11 960.35 1088.71 1570.26

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1398.36 1369.82 1375.58 -0.03 -0.02 0.01
7h 1451.26 1170.02 1386.27 -0.31 -0.07 0.24
23h 1227.14 7267.52 1492.84 2.57 0.28 -2.28

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1398.36 1451.26 1227.14 0.05 -0.19 -0.24
Ebov 1369.82 1170.02 7267.52 -0.23 2.41 2.63
Marv 1375.58 1386.27 1492.84 0.01 0.12 0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 353.02 330.64 304.69 -0.09 -0.21 -0.12
7h 305.98 362.38 364.53 0.24 0.25 0.01
23h 551.91 596.4 457.6 0.11 -0.27 -0.38

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 353.02 305.98 551.91 -0.21 0.64 0.85
Ebov 330.64 362.38 596.4 0.13 0.85 0.72
Marv 304.69 364.53 457.6 0.26 0.59 0.33