PCDHB2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PCDHB2 PCDH-BETA2 protocadherin beta 2 NM_018936 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the protocadherin beta gene cluster, one of three related gene clusters tandemly linked on chromosome five. The gene clusters demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The beta cluster contains 16 genes and 3 pseudogenes, each encoding 6 extracellular cadherin domains and a cytoplasmic tail that deviates from others in the cadherin superfamily. The extracellular domains interact in a homophilic manner to specify differential cell-cell connections. Unlike the alpha and gamma clusters, the transcripts from these genes are made up of only one large exon, not sharing common 3' exons as expected.

Gene well expressed in human cells, highly downregulated in human cells after Ebola infection. Stably expressed in bat cells.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome75 116 81 80 106 18 73 109 79
Read_Max
batR. aegyptiacusTranscriptome 96 77 89 71 63 50 56 95 130
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 883.86 967.84 852.84 887.31 800.13 95.75 847.5 885.08 817.6
DESeq
batR. aegyptiacusTranscriptome 547.09 517.48 722.93 547.65 532.12 339.76 500.47 552.08 626.42
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 883.86 887.31 847.5 0.01 -0.06 -0.07
7h 967.84 800.13 885.08 -0.27 -0.13 0.15
23h 852.84 95.75 817.6 -3.15 -0.06 3.09

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 883.86 967.84 852.84 0.13 -0.05 -0.18
Ebov 887.31 800.13 95.75 -0.15 -3.21 -3.06
Marv 847.5 885.08 817.6 0.06 -0.05 -0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 547.09 547.65 500.47 0.0 -0.13 -0.13
7h 517.48 532.12 552.08 0.04 0.09 0.05
23h 722.93 339.76 626.42 -1.09 -0.21 0.88

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 547.09 517.48 722.93 -0.08 0.4 0.48
Ebov 547.65 532.12 339.76 -0.04 -0.69 -0.65
Marv 500.47 552.08 626.42 0.14 0.32 0.18