FST

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FST FS follistatin NM_013409 pdf

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Description

Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. In a study in which 37 candidate genes were tested for linkage and association with polycystic ovary syndrome (PCOS) or hyperandrogenemia in 150 families, evidence was found for linkage between PCOS and follistatin.

Moderate expression in human cells with downregulation after 23 h of Ebola infection. In bat cells very low expression in all investigated conditions.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome447 468 348 443 585 197 678 875 693
Read_Max
batR. aegyptiacusTranscriptome 43 38 36 39 24 14 30 31 50
Read_Max
bat_genomeR. aegyptiacusGenome 42 38 37 32 18 11 26 38 62
DESeq
humanH. sapiensGenome 4269.19 3951.99 3483.83 4174.76 4364.11 1214.28 5004.58 5630.83 7190.54
DESeq
batR. aegyptiacusTranscriptome 156.43 156.21 308.83 190.54 156.5 65.16 150.06 143.93 257.29
DESeq
bat_genomeR. aegyptiacusGenome 203.68 277.46 455.24 228.11 225.46 122.71 236.15 230.75 420.39

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4269.19 4174.76 5004.58 -0.03 0.23 0.26
7h 3951.99 4364.11 5630.83 0.14 0.51 0.37
23h 3483.83 1214.28 7190.54 -1.52 1.05 2.57

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4269.19 3951.99 3483.83 -0.11 -0.29 -0.18
Ebov 4174.76 4364.11 1214.28 0.06 -1.78 -1.85
Marv 5004.58 5630.83 7190.54 0.17 0.52 0.35

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 156.43 190.54 150.06 0.28 -0.06 -0.34
7h 156.21 156.5 143.93 0.0 -0.12 -0.12
23h 308.83 65.16 257.29 -2.24 -0.26 1.98

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 156.43 156.21 308.83 -0.0 0.98 0.98
Ebov 190.54 156.5 65.16 -0.28 -1.55 -1.26
Marv 150.06 143.93 257.29 -0.06 0.78 0.84