PCDHA3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PCDHA3 PCDH-ALPHA3 protocadherin alpha 3 NM_018906 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined.

Very low expression. Slight downregulation at in human cells Ebola infected cells after 23 h.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome9 10 11 9 10 13 12 13 7
Read_Max
batR. aegyptiacusTranscriptome 52 43 42 47 55 25 48 47 61
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 153.22 185.6 243.25 184.65 174.16 41.79 172.93 204.83 240.22
DESeq
batR. aegyptiacusTranscriptome 208.51 210.68 256.3 227.17 253.97 115.2 221.26 247.21 225.8
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 153.22 184.65 172.93 0.27 0.17 -0.09
7h 185.6 174.16 204.83 -0.09 0.14 0.23
23h 243.25 41.79 240.22 -2.54 -0.02 2.52

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 153.22 185.6 243.25 0.28 0.67 0.39
Ebov 184.65 174.16 41.79 -0.08 -2.14 -2.06
Marv 172.93 204.83 240.22 0.24 0.47 0.23

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 208.51 227.17 221.26 0.12 0.09 -0.04
7h 210.68 253.97 247.21 0.27 0.23 -0.04
23h 256.3 115.2 225.8 -1.15 -0.18 0.97

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 208.51 210.68 256.3 0.01 0.3 0.28
Ebov 227.17 253.97 115.2 0.16 -0.98 -1.14
Marv 221.26 247.21 225.8 0.16 0.03 -0.13