FLCN

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FLCN BHD, MGC17998, MGC23445, folliculin folliculin NM_144606 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The folliculin (FLCN) gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

The FLCN gene is strongly up-regulated in human cells in Ebola virus infected cells and moderately up-regulated in Marburg virus infected cells. In bat cells cells and not infected human cells cells no differential expression is observed.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome112 106 105 113 147 642 127 125 154
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA
DESeq
humanH. sapiensGenome 2484.18 1922.44 2184.22 2495.67 2343.92 12945.73 2249.28 2095.3 3620.78
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome NA NA NA NA NA NA NA NA NA

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2484.18 2495.67 2249.28 0.01 -0.14 -0.15
7h 1922.44 2343.92 2095.3 0.29 0.12 -0.16
23h 2184.22 12945.73 3620.78 2.57 0.73 -1.84

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2484.18 1922.44 2184.22 -0.37 -0.19 0.18
Ebov 2495.67 2343.92 12945.73 -0.09 2.37 2.47
Marv 2249.28 2095.3 3620.78 -0.1 0.69 0.79

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA