FLCN
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| FLCN | BHD, MGC17998, MGC23445, folliculin | folliculin | NM_144606 |  |
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NONE |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The folliculin (FLCN) gene is located within the Smith-Magenis syndrome region on chromosome 17. Mutations in this gene are associated with Birt-Hogg-Dube syndrome, which is characterized by fibrofolliculomas, renal tumors, lung cysts, and pneumothorax. Alternative splicing of this gene results in two transcript variants encoding different isoforms.
The FLCN gene is strongly up-regulated in human cells in Ebola virus infected cells and moderately up-regulated in Marburg virus infected cells. In bat cells cells and not infected human cells cells no differential expression is observed.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 112 | 106 | 105 | 113 | 147 | 642 | 127 | 125 | 154 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | H. sapiens | Genome | 2484.18 | 1922.44 | 2184.22 | 2495.67 | 2343.92 | 12945.73 | 2249.28 | 2095.3 | 3620.78 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | NA | NA | NA | NA | NA | NA | NA | NA | NA |