SDC2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SDC2	B3KQA3, HSPG1,fibroglycan, SYND2, CD362	syndecan 2	NM_002998	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene (SDC2) is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types.

This gene is equally expressed within the wildtype probe, whereas for the virus infected cells a downregulation in the 23 h samples takes place. In the Ebola infected ones it was most significant with a 5x downregulation.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	591	564	546	582	624	146	713	621	355
Read_Max	R. aegyptiacus	Transcriptome	532	468	365	454	353	205	366	498	411
Read_Max	R. aegyptiacus	Genome	759	609	432	733	392	174	454	743	655
DESeq	H. sapiens	Genome	5097.26	4731.17	5714.71	5251.56	5164.05	970.83	4927.38	4422.21	3865.43
DESeq	R. aegyptiacus	Transcriptome	2238.29	2347.38	2462.4	2269.11	2339.02	1212.32	2482.78	2457.32	2045.19
DESeq	R. aegyptiacus	Genome	5784.55	5761.78	5930.36	6379.14	6108.6	3096.43	6750.57	5972.47	5435.1

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5097.26	5251.56	4927.38	0.04	-0.05	-0.09
7h	4731.17	5164.05	4422.21	0.13	-0.1	-0.22
23h	5714.71	970.83	3865.43	-2.56	-0.56	1.99

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5097.26	4731.17	5714.71	-0.11	0.16	0.27
Ebov	5251.56	5164.05	970.83	-0.02	-2.44	-2.41
Marv	4927.38	4422.21	3865.43	-0.16	-0.35	-0.19

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2238.29	2269.11	2482.78	0.02	0.15	0.13
7h	2347.38	2339.02	2457.32	-0.01	0.07	0.07
23h	2462.4	1212.32	2045.19	-1.02	-0.27	0.75

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2238.29	2347.38	2462.4	0.07	0.14	0.07
Ebov	2269.11	2339.02	1212.32	0.04	-0.9	-0.95
Marv	2482.78	2457.32	2045.19	-0.01	-0.28	-0.26

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material