PEG10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PEG10 EDR, HB-1, Mar2, MEF3L, Mart2, RGAG3,KIAA1051 paternally expressed 10 NM_015068 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.

PEG10 is very highly expressed in human cells. In Ebola- and Marburg-infected cells, it is significantly down-regulated after 23h of infection. In addition, there seems to be a processed site at the 5' end of the gene, which also shows a lower expression in Ebola- and Marburg infected cells after 23h. Although reads that map to this site have mate pairs very far away. In the bat homolog, we observe an approx.~10-fold lower expression, which is of a more constant nature across the various conditions.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome6192 5686 4594 4840 7865 1110 5999 6568 1701
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 282 221 119 176 125 78 134 280 172
DESeq
humanH. sapiensGenome 176069.56 156686.11 112075.02 151223.64 148002.75 26623.42 146221.39 129728.38 43220.86
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 4244.53 3934.58 2395.57 4007.21 3666.5 2006.42 3766.06 3512.75 2179.86

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 176069.56 151223.64 146221.39 -0.22 -0.27 -0.05
7h 156686.11 148002.75 129728.38 -0.08 -0.27 -0.19
23h 112075.02 26623.42 43220.86 -2.07 -1.37 0.7

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 176069.56 156686.11 112075.02 -0.17 -0.65 -0.48
Ebov 151223.64 148002.75 26623.42 -0.03 -2.51 -2.47
Marv 146221.39 129728.38 43220.86 -0.17 -1.76 -1.59

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA