PEG10
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| PEG10 | EDR, HB-1, Mar2, MEF3L, Mart2, RGAG3,KIAA1051 | paternally expressed 10 | NM_015068 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas.
PEG10 is very highly expressed in human cells. In Ebola- and Marburg-infected cells, it is significantly down-regulated after 23h of infection. In addition, there seems to be a processed site at the 5' end of the gene, which also shows a lower expression in Ebola- and Marburg infected cells after 23h. Although reads that map to this site have mate pairs very far away. In the bat homolog, we observe an approx.~10-fold lower expression, which is of a more constant nature across the various conditions.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 6192 | 5686 | 4594 | 4840 | 7865 | 1110 | 5999 | 6568 | 1701 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 282 | 221 | 119 | 176 | 125 | 78 | 134 | 280 | 172 |
DESeq | | H. sapiens | Genome | 176069.56 | 156686.11 | 112075.02 | 151223.64 | 148002.75 | 26623.42 | 146221.39 | 129728.38 | 43220.86 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 4244.53 | 3934.58 | 2395.57 | 4007.21 | 3666.5 | 2006.42 | 3766.06 | 3512.75 | 2179.86 |