HBP1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
HBP1 HMG-box transcription factor 1 NM_012257 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The UCSC shown well conserved HBP1 gene is a transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

The annotation misses 3 exons of the 3' end. The sashimiplot shows their assignment to HBP1 and not the upstream UCSC annotated COG5 gene. To the locus of COG5 gene, no reads were mapped to observe a possible transcript and confirm the COG5 annotation. Upstream of the 5' a small transcript can be observed in human cells, which is expressed equally in all samples. The exonic expression is up to 4 fold upregulated in between the Ebola samples and is different to a lower upregulation which goes back to start expression rate after 23 h in Marburg samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome173 178 153 135 183 812 151 196 143
Read_Max
batR. aegyptiacusTranscriptome 136 104 139 139 80 159 87 168 98
Read_Max
bat_genomeR. aegyptiacusGenome 144 153 115 101 77 98 75 203 117
DESeq
humanH. sapiensGenome 1302.97 1418.62 1797.02 1335.6 1606.58 7401.75 1208.91 1239.99 1652.68
DESeq
batR. aegyptiacusTranscriptome 864.66 792.51 1189.56 991.75 850.79 1137.9 904.27 1051.94 754.12
DESeq
bat_genomeR. aegyptiacusGenome 1280.49 1369.03 1600.03 1151.41 1225.51 1668.31 1256.1 1456.64 1075.38

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1302.97 1335.6 1208.91 0.04 -0.11 -0.14
7h 1418.62 1606.58 1239.99 0.18 -0.19 -0.37
23h 1797.02 7401.75 1652.68 2.04 -0.12 -2.16

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1302.97 1418.62 1797.02 0.12 0.46 0.34
Ebov 1335.6 1606.58 7401.75 0.27 2.47 2.2
Marv 1208.91 1239.99 1652.68 0.04 0.45 0.41

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 864.66 991.75 904.27 0.2 0.06 -0.13
7h 792.51 850.79 1051.94 0.1 0.41 0.31
23h 1189.56 1137.9 754.12 -0.06 -0.66 -0.59

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 864.66 792.51 1189.56 -0.13 0.46 0.59
Ebov 991.75 850.79 1137.9 -0.22 0.2 0.42
Marv 904.27 1051.94 754.12 0.22 -0.26 -0.48