HBP1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
HBP1		HMG-box transcription factor 1	NM_012257	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The UCSC shown well conserved HBP1 gene is a transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the H1F0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4.

The annotation misses 3 exons of the 3' end. The sashimiplot shows their assignment to HBP1 and not the upstream UCSC annotated COG5 gene. To the locus of COG5 gene, no reads were mapped to observe a possible transcript and confirm the COG5 annotation. Upstream of the 5' a small transcript can be observed in human cells, which is expressed equally in all samples. The exonic expression is up to 4 fold upregulated in between the Ebola samples and is different to a lower upregulation which goes back to start expression rate after 23 h in Marburg samples.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	173	178	153	135	183	812	151	196	143
Read_Max	R. aegyptiacus	Transcriptome	136	104	139	139	80	159	87	168	98
Read_Max	R. aegyptiacus	Genome	144	153	115	101	77	98	75	203	117
DESeq	H. sapiens	Genome	1302.97	1418.62	1797.02	1335.6	1606.58	7401.75	1208.91	1239.99	1652.68
DESeq	R. aegyptiacus	Transcriptome	864.66	792.51	1189.56	991.75	850.79	1137.9	904.27	1051.94	754.12
DESeq	R. aegyptiacus	Genome	1280.49	1369.03	1600.03	1151.41	1225.51	1668.31	1256.1	1456.64	1075.38

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1302.97	1335.6	1208.91	0.04	-0.11	-0.14
7h	1418.62	1606.58	1239.99	0.18	-0.19	-0.37
23h	1797.02	7401.75	1652.68	2.04	-0.12	-2.16

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1302.97	1418.62	1797.02	0.12	0.46	0.34
Ebov	1335.6	1606.58	7401.75	0.27	2.47	2.2
Marv	1208.91	1239.99	1652.68	0.04	0.45	0.41

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	864.66	991.75	904.27	0.2	0.06	-0.13
7h	792.51	850.79	1051.94	0.1	0.41	0.31
23h	1189.56	1137.9	754.12	-0.06	-0.66	-0.59

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	864.66	792.51	1189.56	-0.13	0.46	0.59
Ebov	991.75	850.79	1137.9	-0.22	0.2	0.42
Marv	904.27	1051.94	754.12	0.22	-0.26	-0.48

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material