OPTN

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
OPTN	NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP,FIP2, HYPL, FIP-2, TFIIIA-INTP, NRP, HIP7	optineurin	NM_021980	pdf			NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

OPTN is significantly up-regulated in Ebola-infected human cells after 23h of infection and slightly upregulated in cells infected with the Marburg virus, also after 23h of infection. In the bat homolog, there is a steady up-regulation in both Ebola- and Marburg-infected cells, but not in the wild type. In addition, there is some indication of an alternate exon being expressed in few cases, which is not in the human annotation file.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	140	192	154	158	192	954	227	210	330
Read_Max	R. aegyptiacus	Transcriptome	249	171	247	224	228	413	203	315	507
Read_Max	R. aegyptiacus	Genome	292	249	215	168	200	254	178	400	592
DESeq	H. sapiens	Genome	1326.31	1503.27	1988.63	1464.5	1641.53	8058.39	1551.9	1367.09	4240.57
DESeq	R. aegyptiacus	Transcriptome	1872.83	1664.8	2397.66	2120.77	2123.28	3214.09	2027.8	2247.46	3062.48
DESeq	R. aegyptiacus	Genome	2227.54	2430.48	2561.83	2065.82	2478.93	3615.99	2246.82	2489.06	3320.31

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1326.31	1464.5	1551.9	0.14	0.23	0.08
7h	1503.27	1641.53	1367.09	0.13	-0.14	-0.26
23h	1988.63	8058.39	4240.57	2.02	1.09	-0.93

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1326.31	1503.27	1988.63	0.18	0.58	0.4
Ebov	1464.5	1641.53	8058.39	0.16	2.46	2.3
Marv	1551.9	1367.09	4240.57	-0.18	1.45	1.63

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1872.83	2120.77	2027.8	0.18	0.11	-0.06
7h	1664.8	2123.28	2247.46	0.35	0.43	0.08
23h	2397.66	3214.09	3062.48	0.42	0.35	-0.07

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1872.83	1664.8	2397.66	-0.17	0.36	0.53
Ebov	2120.77	2123.28	3214.09	0.0	0.6	0.6
Marv	2027.8	2247.46	3062.48	0.15	0.59	0.45

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material