OPTN

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
OPTN NRP, FIP2, HIP7, HYPL, ALS12, GLC1E, TFIIIA-INTP,FIP2, HYPL, FIP-2, TFIIIA-INTP, NRP, HIP7 optineurin NM_021980 pdf NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

OPTN is significantly up-regulated in Ebola-infected human cells after 23h of infection and slightly upregulated in cells infected with the Marburg virus, also after 23h of infection. In the bat homolog, there is a steady up-regulation in both Ebola- and Marburg-infected cells, but not in the wild type. In addition, there is some indication of an alternate exon being expressed in few cases, which is not in the human annotation file.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome140 192 154 158 192 954 227 210 330
Read_Max
batR. aegyptiacusTranscriptome 249 171 247 224 228 413 203 315 507
Read_Max
bat_genomeR. aegyptiacusGenome 292 249 215 168 200 254 178 400 592
DESeq
humanH. sapiensGenome 1326.31 1503.27 1988.63 1464.5 1641.53 8058.39 1551.9 1367.09 4240.57
DESeq
batR. aegyptiacusTranscriptome 1872.83 1664.8 2397.66 2120.77 2123.28 3214.09 2027.8 2247.46 3062.48
DESeq
bat_genomeR. aegyptiacusGenome 2227.54 2430.48 2561.83 2065.82 2478.93 3615.99 2246.82 2489.06 3320.31

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1326.31 1464.5 1551.9 0.14 0.23 0.08
7h 1503.27 1641.53 1367.09 0.13 -0.14 -0.26
23h 1988.63 8058.39 4240.57 2.02 1.09 -0.93

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1326.31 1503.27 1988.63 0.18 0.58 0.4
Ebov 1464.5 1641.53 8058.39 0.16 2.46 2.3
Marv 1551.9 1367.09 4240.57 -0.18 1.45 1.63

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 1872.83 2120.77 2027.8 0.18 0.11 -0.06
7h 1664.8 2123.28 2247.46 0.35 0.43 0.08
23h 2397.66 3214.09 3062.48 0.42 0.35 -0.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 1872.83 1664.8 2397.66 -0.17 0.36 0.53
Ebov 2120.77 2123.28 3214.09 0.0 0.6 0.6
Marv 2027.8 2247.46 3062.48 0.15 0.59 0.45