SHC4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
SHC4	SCK, SHCB, SLI,RaLP	SHC (Src homology 2 domain containing) family, member 4	NM_203349	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The SHC (Src homology 2 domain containing) family, member 4 is involved in the ErbB, Ras, Chemokine, Neurotrophin, Insulin, Estrogen and Prolactin signaling pathways. Also in focal adhesion, natural killer cell mediated cytotoxicity, alcoholism, bacterial invasion of epithelial cells, microRNAs in cancer, glioma and chronic myeloid leukemia. Very low expression in bats. It seems to be upregulated after 23 hours of Ebola infection in humans.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	395	490	438	514	508	143	592	683	422
Read_Max	R. aegyptiacus	Transcriptome	1	NA	NA	NA	NA	NA	NA	1	NA
Read_Max	R. aegyptiacus	Genome	961	741	660	807	559	376	639	1087	1236
DESeq	H. sapiens	Genome	2261.95	2655.73	2388.74	2698.72	2310.59	497.1	2717.7	2519.75	2654.13
DESeq	R. aegyptiacus	Transcriptome	1.84	1.0	1.0	1.0	1.0	1.0	1.0	1.83	1.0
DESeq	R. aegyptiacus	Genome	4687.11	4532.39	5344.58	5136.89	4945.59	3943.64	5646.28	4761.64	5774.16

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2261.95	2698.72	2717.7	0.25	0.26	0.01
7h	2655.73	2310.59	2519.75	-0.2	-0.08	0.13
23h	2388.74	497.1	2654.13	-2.26	0.15	2.42

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2261.95	2655.73	2388.74	0.23	0.08	-0.15
Ebov	2698.72	2310.59	497.1	-0.22	-2.44	-2.22
Marv	2717.7	2519.75	2654.13	-0.11	-0.03	0.07

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1.84	1.0	1.0	-0.88	-0.88	0.0
7h	1.0	1.0	1.83	0.0	0.87	0.87
23h	1.0	1.0	1.0	0.0	0.0	0.0

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1.84	1.0	1.0	-0.88	-0.88	0.0
Ebov	1.0	1.0	1.0	0.0	0.0	0.0
Marv	1.0	1.83	1.0	0.87	0.0	-0.87

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material