AHR

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
AHR	A4D130, AHR_HUMAN, BHLHE76, NM_001621, NP_001612, P35869, Q13728, Q13803, Q13804,bHLHe76	aryl hydrocarbon receptor	NM_001621	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450 (e.g. activates CYP1A1). Its ligands included a variety of aromatic hydrocarbons. Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Its expression pattern shows upregulation in human cells Ebola infected cells after 7 h and 23 h, whereas in the wildtype it is downregulated over time. The bat cells transcripts do not show differential expression.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	273	237	164	206	246	985	255	357	363
Read_Max	R. aegyptiacus	Transcriptome	221	164	130	159	95	83	134	152	135
Read_Max	R. aegyptiacus	Genome	236	173	107	141	82	51	112	185	137
DESeq	H. sapiens	Genome	5870.53	4093.75	3412.35	4707.46	3660.9	18296.27	4587.03	4584.48	8288.76
DESeq	R. aegyptiacus	Transcriptome	2197.13	1809.12	1731.92	1709.64	1364.39	1119.93	1835.36	1524.53	1178.36
DESeq	R. aegyptiacus	Genome	2651.22	2072.71	2153.45	2249.49	1750.1	1464.67	2341.28	1952.23	1433.26

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5870.53	4707.46	4587.03	-0.32	-0.36	-0.04
7h	4093.75	3660.9	4584.48	-0.16	0.16	0.32
23h	3412.35	18296.27	8288.76	2.42	1.28	-1.14

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5870.53	4093.75	3412.35	-0.52	-0.78	-0.26
Ebov	4707.46	3660.9	18296.27	-0.36	1.96	2.32
Marv	4587.03	4584.48	8288.76	-0.0	0.85	0.85

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2197.13	1709.64	1835.36	-0.36	-0.26	0.1
7h	1809.12	1364.39	1524.53	-0.41	-0.25	0.16
23h	1731.92	1119.93	1178.36	-0.63	-0.56	0.07

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2197.13	1809.12	1731.92	-0.28	-0.34	-0.06
Ebov	1709.64	1364.39	1119.93	-0.33	-0.61	-0.28
Marv	1835.36	1524.53	1178.36	-0.27	-0.64	-0.37

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material

AHR