AHR

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
AHR A4D130, AHR_HUMAN, BHLHE76, NM_001621, NP_001612, P35869, Q13728, Q13803, Q13804,bHLHe76 aryl hydrocarbon receptor NM_001621 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450 (e.g. activates CYP1A1). Its ligands included a variety of aromatic hydrocarbons. Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues. Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1. Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1.

Its expression pattern shows upregulation in human cells Ebola infected cells after 7 h and 23 h, whereas in the wildtype it is downregulated over time. The bat cells transcripts do not show differential expression.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome273 237 164 206 246 985 255 357 363
Read_Max
batR. aegyptiacusTranscriptome 221 164 130 159 95 83 134 152 135
Read_Max
bat_genomeR. aegyptiacusGenome 236 173 107 141 82 51 112 185 137
DESeq
humanH. sapiensGenome 5870.53 4093.75 3412.35 4707.46 3660.9 18296.27 4587.03 4584.48 8288.76
DESeq
batR. aegyptiacusTranscriptome 2197.13 1809.12 1731.92 1709.64 1364.39 1119.93 1835.36 1524.53 1178.36
DESeq
bat_genomeR. aegyptiacusGenome 2651.22 2072.71 2153.45 2249.49 1750.1 1464.67 2341.28 1952.23 1433.26

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 5870.53 4707.46 4587.03 -0.32 -0.36 -0.04
7h 4093.75 3660.9 4584.48 -0.16 0.16 0.32
23h 3412.35 18296.27 8288.76 2.42 1.28 -1.14

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 5870.53 4093.75 3412.35 -0.52 -0.78 -0.26
Ebov 4707.46 3660.9 18296.27 -0.36 1.96 2.32
Marv 4587.03 4584.48 8288.76 -0.0 0.85 0.85

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2197.13 1709.64 1835.36 -0.36 -0.26 0.1
7h 1809.12 1364.39 1524.53 -0.41 -0.25 0.16
23h 1731.92 1119.93 1178.36 -0.63 -0.56 0.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2197.13 1809.12 1731.92 -0.28 -0.34 -0.06
Ebov 1709.64 1364.39 1119.93 -0.33 -0.61 -0.28
Marv 1835.36 1524.53 1178.36 -0.27 -0.64 -0.37