FAM53C

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
FAM53C	B2RDJ5, C5orf6, D3DQB9, FA53C_HUMAN, NM_001135647, NP_057689, Q9NYF3	family with sequence similarity 53, member C	NM_016605	pdf

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Description

Homo sapiens family with sequence similarity 53, member C (FAM53C), transcript variant 1, mRNA. Experimental validated, but exact function unclear, belongs to Acetylation- and Phosphoprotein.

It is strongly expressed during Ebola infection in human cells after 23 h. It also shows expression over all introns, which are upregulated for Ebola samples, while the third intron is even downregulated in human cells Marburg infected samples. In comparison, the homolog sequence in bat cells does not show any expression profile changes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	128	143	129	136	160	845	161	204	144
Read_Max	R. aegyptiacus	Transcriptome	90	87	102	125	97	145	98	113	117
Read_Max	R. aegyptiacus	Genome	145	130	92	99	85	79	83	172	123
DESeq	H. sapiens	Genome	2633.36	2570.06	2471.15	2772.86	2537.41	13027.31	2966.83	2817.91	3170.62
DESeq	R. aegyptiacus	Transcriptome	583.22	605.52	718.04	652.04	662.43	699.05	633.96	557.04	542.44
DESeq	R. aegyptiacus	Genome	1610.5	1703.98	1808.68	1702.42	1832.69	2082.13	1758.77	1636.64	1562.55

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2633.36	2772.86	2966.83	0.07	0.17	0.1
7h	2570.06	2537.41	2817.91	-0.02	0.13	0.15
23h	2471.15	13027.31	3170.62	2.4	0.36	-2.04

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2633.36	2570.06	2471.15	-0.04	-0.09	-0.06
Ebov	2772.86	2537.41	13027.31	-0.13	2.23	2.36
Marv	2966.83	2817.91	3170.62	-0.07	0.1	0.17

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	583.22	652.04	633.96	0.16	0.12	-0.04
7h	605.52	662.43	557.04	0.13	-0.12	-0.25
23h	718.04	699.05	542.44	-0.04	-0.4	-0.37

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	583.22	605.52	718.04	0.05	0.3	0.25
Ebov	652.04	662.43	699.05	0.02	0.1	0.08
Marv	633.96	557.04	542.44	-0.19	-0.22	-0.04

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material