BCAT1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
BCAT1		branched chain amino-acid transaminase 1, cytosolic	NM_005504	pdf		NONE

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described.

The gene is rather high expressed in all conditions only in the human cells Ebola 23 h sample it is down regulated by a factor of 6. There exists a good homolog in bat cells with equally expressions in all time points.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	586	634	735	434	723	158	466	680	542
Read_Max	R. aegyptiacus	Transcriptome	54	43	54	84	58	89	34	65	118
Read_Max	R. aegyptiacus	Genome	55	69	45	35	47	47	24	79	119
DESeq	H. sapiens	Genome	15085.81	13709.11	22623.5	12689.96	16546.99	4298.8	11514.31	11519.64	19000.21
DESeq	R. aegyptiacus	Transcriptome	216.08	194.34	399.22	391.07	419.32	566.88	221.26	351.31	612.42
DESeq	R. aegyptiacus	Genome	242.35	395.19	412.84	224.16	410.74	558.72	236.15	382.99	661.84

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	15085.81	12689.96	11514.31	-0.25	-0.39	-0.14
7h	13709.11	16546.99	11519.64	0.27	-0.25	-0.52
23h	22623.5	4298.8	19000.21	-2.4	-0.25	2.14

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	15085.81	13709.11	22623.5	-0.14	0.58	0.72
Ebov	12689.96	16546.99	4298.8	0.38	-1.56	-1.94
Marv	11514.31	11519.64	19000.21	0.0	0.72	0.72

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	216.08	391.07	221.26	0.86	0.03	-0.82
7h	194.34	419.32	351.31	1.11	0.85	-0.26
23h	399.22	566.88	612.42	0.51	0.62	0.11

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	216.08	194.34	399.22	-0.15	0.89	1.04
Ebov	391.07	419.32	566.88	0.1	0.54	0.43
Marv	221.26	351.31	612.42	0.67	1.47	0.8

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material