LATS2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
LATS2 AK314235, B1AM47, KPM, LATS2_HUMAN, NM_014572, NP_055387, Q9NRM7, Q9P2X1 large tumor suppressor kinase 2 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.

The gene is upregulated in human cells Ebola infected cells after 23 h.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome144 93 103 119 137 575 143 115 137
Read_Max
batR. aegyptiacusTranscriptome 134 103 121 88 99 133 93 85 108
Read_Max
bat_genomeR. aegyptiacusGenome 128 82 94 99 78 102 76 108 133
DESeq
humanH. sapiensGenome 3208.74 2175.37 1939.99 2850.43 2017.12 9877.0 2991.39 2131.27 2841.15
DESeq
batR. aegyptiacusTranscriptome 952.88 970.41 1123.59 739.94 835.46 1329.09 1056.67 733.85 895.83
DESeq
bat_genomeR. aegyptiacusGenome 1815.03 1567.99 1909.1 1839.68 1605.0 2374.54 1877.97 1498.67 1700.4

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 3208.74 2850.43 2991.39 -0.17 -0.1 0.07
7h 2175.37 2017.12 2131.27 -0.11 -0.03 0.08
23h 1939.99 9877.0 2841.15 2.35 0.55 -1.8

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 3208.74 2175.37 1939.99 -0.56 -0.73 -0.17
Ebov 2850.43 2017.12 9877.0 -0.5 1.79 2.29
Marv 2991.39 2131.27 2841.15 -0.49 -0.07 0.41

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 952.88 739.94 1056.67 -0.36 0.15 0.51
7h 970.41 835.46 733.85 -0.22 -0.4 -0.19
23h 1123.59 1329.09 895.83 0.24 -0.33 -0.57

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 952.88 970.41 1123.59 0.03 0.24 0.21
Ebov 739.94 835.46 1329.09 0.18 0.84 0.67
Marv 1056.67 733.85 895.83 -0.53 -0.24 0.29