LATS2
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| LATS2 | AK314235, B1AM47, KPM, LATS2_HUMAN, NM_014572, NP_055387, Q9NRM7, Q9P2X1 | large tumor suppressor kinase 2 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression.
The gene is upregulated in human cells Ebola infected cells after 23 h.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 144 | 93 | 103 | 119 | 137 | 575 | 143 | 115 | 137 |
Read_Max |  | R. aegyptiacus | Transcriptome | 134 | 103 | 121 | 88 | 99 | 133 | 93 | 85 | 108 |
Read_Max |  | R. aegyptiacus | Genome | 128 | 82 | 94 | 99 | 78 | 102 | 76 | 108 | 133 |
DESeq | | H. sapiens | Genome | 3208.74 | 2175.37 | 1939.99 | 2850.43 | 2017.12 | 9877.0 | 2991.39 | 2131.27 | 2841.15 |
DESeq | | R. aegyptiacus | Transcriptome | 952.88 | 970.41 | 1123.59 | 739.94 | 835.46 | 1329.09 | 1056.67 | 733.85 | 895.83 |
DESeq | | R. aegyptiacus | Genome | 1815.03 | 1567.99 | 1909.1 | 1839.68 | 1605.0 | 2374.54 | 1877.97 | 1498.67 | 1700.4 |