SLC3A2
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| SLC3A2 | hCG_2016598, J3KPF3, J3KPF3_HUMAN, NM_001012662, NP_001013269,4T2HC, 4F2, NACAE, CD98, CD98HC, 4F2HC | solute carrier family 3 (amino acid transporter heavy chain), member 2 | NM_001012661 |  |
 |
NONE |  |
Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
Homo sapiens solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2 (SLC3A2), transcript variant 2 gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized.
Upstream, in the human cells small nucleolar RNA host gene 1 (non-protein coding) (SNHG1), non-coding RNA locus, C/D-box snoRNAs are encoded. It is commonly known, that these ncRNAs do not regulate transcription. But we observed in the human cells genome an increase of expression rate: equal for MOCK, upregulated during Ebola infection and downregulated during Marburg infection.
A similar pattern is shown for the strongly expressed SLC3A2 gene in Ebola infected samples. It is 4 fold upregulated in 7 h to 23 h comparison, whereas the human cells MOCK samples show a lower and over time equal expression rate. In contrast, the bat cells transcriptome homologs are downregulated in the wildtype and upregulated during Ebola and Marburg (lower increase) infection.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 396 | 403 | 452 | 417 | 566 | 2369 | 472 | 599 | 785 |
Read_Max |  | R. aegyptiacus | Transcriptome | 343 | 389 | 278 | 268 | 215 | 544 | 237 | 302 | 570 |
Read_Max |  | R. aegyptiacus | Genome | 514 | 325 | 245 | 376 | 188 | 343 | 213 | 401 | 640 |
DESeq | | H. sapiens | Genome | 4470.12 | 4369.12 | 4054.7 | 4422.29 | 4321.83 | 19514.81 | 4452.81 | 5399.01 | 7775.53 |
DESeq | | R. aegyptiacus | Transcriptome | 2529.82 | 2973.68 | 2666.39 | 2186.7 | 2139.71 | 4584.52 | 2476.1 | 2257.38 | 3853.22 |
DESeq | | R. aegyptiacus | Genome | 2827.39 | 2403.1 | 2668.94 | 3352.51 | 2465.54 | 4767.36 | 2682.01 | 2457.34 | 3959.89 |