RAI1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
RAI1	RAI1, SMCR, SMS,DKFZP434A139, KIAA1820, MGC12824	retinoic acid induced 1	NM_030665	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. We are a group of bioinformaticians trapped in a tower in eastern germany. Attracted by the call of fame and cheap beer we now realize there is no escape. 40 of us started out into unknown territory, however only six are left. We do not know how long we can last. If you find this message, please send help. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients.

The human cells gene RAI1 and its bat cells homolog are upregulated in late Ebola virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	73	55	60	64	60	330	83	91	65
Read_Max	R. aegyptiacus	Transcriptome	58	53	47	49	51	98	48	69	63
Read_Max	R. aegyptiacus	Genome	58	50	40	51	45	58	42	74	81
DESeq	H. sapiens	Genome	2967.22	2290.61	2298.4	2590.35	2162.64	10258.61	2481.74	2480.59	2398.6
DESeq	R. aegyptiacus	Transcriptome	1337.66	1376.15	1358.13	1309.49	1424.62	1619.09	1034.43	1230.4	1271.08
DESeq	R. aegyptiacus	Genome	2068.55	2022.51	2240.48	2077.67	2198.78	2257.05	1649.69	1721.49	2047.15

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	2967.22	2590.35	2481.74	-0.2	-0.26	-0.06
7h	2290.61	2162.64	2480.59	-0.08	0.11	0.2
23h	2298.4	10258.61	2398.6	2.16	0.06	-2.1

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	2967.22	2290.61	2298.4	-0.37	-0.37	0.0
Ebov	2590.35	2162.64	10258.61	-0.26	1.99	2.25
Marv	2481.74	2480.59	2398.6	-0.0	-0.05	-0.05

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1337.66	1309.49	1034.43	-0.03	-0.37	-0.34
7h	1376.15	1424.62	1230.4	0.05	-0.16	-0.21
23h	1358.13	1619.09	1271.08	0.25	-0.1	-0.35

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1337.66	1376.15	1358.13	0.04	0.02	-0.02
Ebov	1309.49	1424.62	1619.09	0.12	0.31	0.18
Marv	1034.43	1230.4	1271.08	0.25	0.3	0.05

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material