PPP1R10

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PPP1R10 MYO16, MYAP3, MYR8, Myo16b, NYAP3, PPP1R107,PNUTS, FB19, CAT53, p99 protein phosphatase 1, regulatory subunit 10 NM_002714 pdf

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Description

This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. The gene is expressed in bat and human. It is upregulated upon EBOV infection in human (3fold), but not in bat, where it is even slightly downregulated.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome159 156 174 107 209 697 146 207 225
Read_Max
batR. aegyptiacusTranscriptome 238 219 187 247 189 158 128 274 258
Read_Max
bat_genomeR. aegyptiacusGenome 432 336 260 310 242 142 176 436 404
DESeq
humanH. sapiensGenome 2448.67 2762.82 2629.01 2080.47 2603.26 9642.76 2048.4 2755.56 3348.94
DESeq
batR. aegyptiacusTranscriptome 2313.91 2392.76 2644.41 2990.66 2971.98 2415.95 2165.74 3173.64 2903.28
DESeq
bat_genomeR. aegyptiacusGenome 5163.22 6204.43 6357.7 5291.92 6299.46 4818.27 4980.55 6947.79 6191.98

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2448.67 2080.47 2048.4 -0.24 -0.26 -0.02
7h 2762.82 2603.26 2755.56 -0.09 -0.0 0.08
23h 2629.01 9642.76 3348.94 1.87 0.35 -1.53

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2448.67 2762.82 2629.01 0.17 0.1 -0.07
Ebov 2080.47 2603.26 9642.76 0.32 2.21 1.89
Marv 2048.4 2755.56 3348.94 0.43 0.71 0.28

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 2313.91 2990.66 2165.74 0.37 -0.1 -0.47
7h 2392.76 2971.98 3173.64 0.31 0.41 0.09
23h 2644.41 2415.95 2903.28 -0.13 0.13 0.27

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 2313.91 2392.76 2644.41 0.05 0.19 0.14
Ebov 2990.66 2971.98 2415.95 -0.01 -0.31 -0.3
Marv 2165.74 3173.64 2903.28 0.55 0.42 -0.13