VAV3
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| VAV3 | vav 3 guanine nucleotide exchange factor | NM_006113 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.Very lowly expressed in human, with decrease in MARV 23h. No bat homolog found.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 13 | 21 | 11 | 48 | 12 | 21 | 19 | 20 | 12 |
Read_Max |  | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
Read_Max |  | R. aegyptiacus | Genome | 1 | 0 | 2 | 0 | 2 | 2 | 0 | 0 | 2 |
DESeq | | H. sapiens | Genome | 95.38 | 90.75 | 87.38 | 76.29 | 103.43 | 27.32 | 77.32 | 103.32 | 121.7 |
DESeq | | R. aegyptiacus | Transcriptome | NA | NA | NA | NA | NA | NA | NA | NA | NA |
DESeq | | R. aegyptiacus | Genome | 0.86 | 0.0 | 2.23 | 0.0 | 2.23 | 3.92 | 0.0 | 0.0 | 1.71 |