VAV3

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
VAV3 vav 3 guanine nucleotide exchange factor NM_006113 pdf

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Description

This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.Very lowly expressed in human, with decrease in MARV 23h. No bat homolog found.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome13 21 11 48 12 21 19 20 12
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 1 0 2 0 2 2 0 0 2
DESeq
humanH. sapiensGenome 95.38 90.75 87.38 76.29 103.43 27.32 77.32 103.32 121.7
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 0.86 0.0 2.23 0.0 2.23 3.92 0.0 0.0 1.71

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 95.38 76.29 77.32 -0.32 -0.3 0.02
7h 90.75 103.43 103.32 0.19 0.19 -0.0
23h 87.38 27.32 121.7 -1.68 0.48 2.16

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 95.38 90.75 87.38 -0.07 -0.13 -0.05
Ebov 76.29 103.43 27.32 0.44 -1.48 -1.92
Marv 77.32 103.32 121.7 0.42 0.65 0.24

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA