SLC7A11

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
SLC7A11 A8K2U4, NM_014331, NP_055146, Q9UPY5, XCT_HUMAN,xCT solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 pdf

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Description

This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. This gene is also upregulated in the infected human and bat cell lines, for EBOV as well as for MARV.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome189 236 223 153 320 127 192 408 414
Read_Max
batR. aegyptiacusTranscriptome 43 40 89 93 95 124 45 91 200
Read_Max
bat_genomeR. aegyptiacusGenome 48 113 78 41 79 73 40 130 230
DESeq
humanH. sapiensGenome 4510.71 5764.3 7134.45 3944.34 7156.59 3369.76 4135.27 7025.69 15453.29
DESeq
batR. aegyptiacusTranscriptome 333.7 283.29 892.72 848.91 880.36 1140.47 305.8 794.16 1391.79
DESeq
bat_genomeR. aegyptiacusGenome 1183.38 3064.8 3184.43 945.02 3087.23 4118.57 1160.52 2715.84 5197.08

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 4510.71 3944.34 4135.27 -0.19 -0.13 0.07
7h 5764.3 7156.59 7025.69 0.31 0.29 -0.03
23h 7134.45 3369.76 15453.29 -1.08 1.12 2.2

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 4510.71 5764.3 7134.45 0.35 0.66 0.31
Ebov 3944.34 7156.59 3369.76 0.86 -0.23 -1.09
Marv 4135.27 7025.69 15453.29 0.76 1.9 1.14

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 333.7 848.91 305.8 1.35 -0.13 -1.47
7h 283.29 880.36 794.16 1.64 1.49 -0.15
23h 892.72 1140.47 1391.79 0.35 0.64 0.29

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 333.7 283.29 892.72 -0.24 1.42 1.66
Ebov 848.91 880.36 1140.47 0.05 0.43 0.37
Marv 305.8 794.16 1391.79 1.38 2.19 0.81