EPHA2

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
EPHA2 ARCC2, CTPA, CTPP1, CTRCT6, ECK EPH receptor A2 NM_004431 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene belongs to the ephrin receptor subfamily of the protein-tyrosinekinase family. EPH and EPH-related receptors have been implicated inmediating developmental events, particularly in the nervous system.Receptors in the EPH subfamily typically have a single kinase domain and anextracellular region containing a Cys-rich domain and 2 fibronectin type IIIrepeats. The ephrin receptors are divided into 2 groups based on thesimilarity of their extracellular domain sequences and their affinities forbinding ephrin-A and ephrin-B ligands. This gene encodes a protein thatbinds ephrin-A ligands. Mutations in this gene are the cause of certaingenetically-related cataract disorders.

The gene is highly expressed in human cells and bat cells, and upregulated in earlyMarburg and late Ebola infection.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome263 294 208 227 254 972 341 445 280
Read_Max
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
Read_Max
bat_genomeR. aegyptiacusGenome 122 141 161 116 110 151 84 236 293
DESeq
humanH. sapiensGenome 6263.25 7030.98 4720.89 5868.67 4896.59 21284.73 6757.23 7892.19 6708.84
DESeq
batR. aegyptiacusTranscriptome NA NA NA NA NA NA NA NA NA
DESeq
bat_genomeR. aegyptiacusGenome 2107.22 2871.31 3865.05 2375.89 2958.87 4893.98 1904.96 2771.35 4092.6

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 6263.25 5868.67 6757.23 -0.09 0.11 0.2
7h 7030.98 4896.59 7892.19 -0.52 0.17 0.69
23h 4720.89 21284.73 6708.84 2.17 0.51 -1.67

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 6263.25 7030.98 4720.89 0.17 -0.41 -0.57
Ebov 5868.67 4896.59 21284.73 -0.26 1.86 2.12
Marv 6757.23 7892.19 6708.84 0.22 -0.01 -0.23

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h NA NA NA NA NA NA
7h NA NA NA NA NA NA
23h NA NA NA NA NA NA

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock NA NA NA NA NA NA
Ebov NA NA NA NA NA NA
Marv NA NA NA NA NA NA