ALDH3A2

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
ALDH3A2	ALDH3A2, ALDH10, FALDH, SLS,FALDH	aldehyde dehydrogenase 3 family, member A2		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This gene product catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acid. Mutations in the gene cause Sjogren-Larsson syndrome.

ALDH3A2 shows a strong downregulation in human cells cells in late phase of Ebola virus infection.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	398	400	348	347	576	166	478	649	500
Read_Max	R. aegyptiacus	Transcriptome	579	536	329	465	402	410	417	550	499
Read_Max	R. aegyptiacus	Genome	625	500	281	508	338	225	358	656	512
DESeq	H. sapiens	Genome	5502.16	5759.2	5539.97	5466.01	5794.9	1764.34	5810.73	7112.02	7928.85
DESeq	R. aegyptiacus	Transcriptome	3683.34	3574.57	3005.98	3284.59	3341.02	2962.58	3713.1	3444.64	3240.05
DESeq	R. aegyptiacus	Genome	5747.6	4856.4	4362.69	5665.19	5067.25	4783.02	5855.44	5143.05	5154.27

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	5502.16	5466.01	5810.73	-0.01	0.08	0.09
7h	5759.2	5794.9	7112.02	0.01	0.3	0.3
23h	5539.97	1764.34	7928.85	-1.65	0.52	2.17

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	5502.16	5759.2	5539.97	0.07	0.01	-0.06
Ebov	5466.01	5794.9	1764.34	0.08	-1.63	-1.72
Marv	5810.73	7112.02	7928.85	0.29	0.45	0.16

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	3683.34	3284.59	3713.1	-0.17	0.01	0.18
7h	3574.57	3341.02	3444.64	-0.1	-0.05	0.04
23h	3005.98	2962.58	3240.05	-0.02	0.11	0.13

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	3683.34	3574.57	3005.98	-0.04	-0.29	-0.25
Ebov	3284.59	3341.02	2962.58	0.02	-0.15	-0.17
Marv	3713.1	3444.64	3240.05	-0.11	-0.2	-0.09

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material