FLNB

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
FLNB FLN1L, FLN3, NM_001164317,TAP, TABP, ABP-278, FH1 filamin B, beta NM_001457 pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The gene FLNB encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

This gene is upregulated twofold in the Ebola 23 h probe. The other samples show slight downregualtion at this timepoint.

Show legend

Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome241 291 189 241 353 900 344 385 211
Read_Max
batR. aegyptiacusTranscriptome 252 213 164 169 161 173 158 187 204
Read_Max
bat_genomeR. aegyptiacusGenome 284 160 132 193 126 113 136 226 257
DESeq
humanH. sapiensGenome 8551.59 8966.7 5964.9 8859.55 8444.31 25170.64 9716.04 9851.4 9452.22
DESeq
batR. aegyptiacusTranscriptome 7695.01 6553.61 6771.98 5935.45 5884.92 6483.63 6431.82 5437.45 6814.11
DESeq
bat_genomeR. aegyptiacusGenome 8655.78 6595.06 7144.32 7774.46 6715.78 7546.57 7577.1 6077.93 7766.51

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 8551.59 8859.55 9716.04 0.05 0.18 0.13
7h 8966.7 8444.31 9851.4 -0.09 0.14 0.22
23h 5964.9 25170.64 9452.22 2.08 0.66 -1.41

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 8551.59 8966.7 5964.9 0.07 -0.52 -0.59
Ebov 8859.55 8444.31 25170.64 -0.07 1.51 1.58
Marv 9716.04 9851.4 9452.22 0.02 -0.04 -0.06

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7695.01 5935.45 6431.82 -0.37 -0.26 0.12
7h 6553.61 5884.92 5437.45 -0.16 -0.27 -0.11
23h 6771.98 6483.63 6814.11 -0.06 0.01 0.07

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7695.01 6553.61 6771.98 -0.23 -0.18 0.05
Ebov 5935.45 5884.92 6483.63 -0.01 0.13 0.14
Marv 6431.82 5437.45 6814.11 -0.24 0.08 0.33