FLNB
| Name | Synonyms | Full Name | RefSeq ID | Description (.pdf) | IGV-img (humangenome) | Sashimi-img (humangenome) | UCSC-img (humangenome) | IGV-img (batgenome) |
|---|---|---|---|---|---|---|---|---|
| FLNB | FLN1L, FLN3, NM_001164317,TAP, TABP, ABP-278, FH1 | filamin B, beta | NM_001457 |  |
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Download all snapshots for IGV, UCSC and Sashimi (zip archive)
Description
The gene FLNB encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.
This gene is upregulated twofold in the Ebola 23 h probe. The other samples show slight downregualtion at this timepoint.
Maximum read counts and DESeq normalized read counts for human and bat cell lines
| Source | Species | Mapping on | Mock3h | Mock7h | Mock23h | EBOV3h | EBOV7h | EBOV23h | MARV3h | MARV7h | MARV23h | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Read_Max |  | H. sapiens | Genome | 241 | 291 | 189 | 241 | 353 | 900 | 344 | 385 | 211 |
Read_Max |  | R. aegyptiacus | Transcriptome | 252 | 213 | 164 | 169 | 161 | 173 | 158 | 187 | 204 |
Read_Max |  | R. aegyptiacus | Genome | 284 | 160 | 132 | 193 | 126 | 113 | 136 | 226 | 257 |
DESeq | | H. sapiens | Genome | 8551.59 | 8966.7 | 5964.9 | 8859.55 | 8444.31 | 25170.64 | 9716.04 | 9851.4 | 9452.22 |
DESeq | | R. aegyptiacus | Transcriptome | 7695.01 | 6553.61 | 6771.98 | 5935.45 | 5884.92 | 6483.63 | 6431.82 | 5437.45 | 6814.11 |
DESeq | | R. aegyptiacus | Genome | 8655.78 | 6595.06 | 7144.32 | 7774.46 | 6715.78 | 7546.57 | 7577.1 | 6077.93 | 7766.51 |