MCM6

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
MCM6 Mis5 minichromosome maintenance complex component 6 NM_005915 pdf

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Description

Homo sapiens minichromosome maintenance complex component 6 (MCM6), mRNA. The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre\_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication. Single nucleotide polymorphisms in the intron regions of this gene are associated with differential transcriptional activation of the promoter of the neighboring lactase gene and, thereby, influence lactose intolerance in early adulthood. [provided by RefSeq, May 2012]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome773 815 849 793 1141 288 1101 1141 477
Read_Max
batR. aegyptiacusTranscriptome 696 659 317 586 481 432 507 614 503
Read_Max
bat_genomeR. aegyptiacusGenome 808 720 438 664 605 409 539 1064 788
DESeq
humanH. sapiensGenome 9522.75 8390.47 8707.08 9540.53 8334.56 2311.76 9833.59 8203.93 4591.78
DESeq
batR. aegyptiacusTranscriptome 7161.52 6740.6 5005.64 6835.55 7043.52 5842.04 7405.17 7168.36 5884.29
DESeq
bat_genomeR. aegyptiacusGenome 8458.98 8034.37 5415.99 8403.49 8386.63 7148.42 9082.85 8073.78 6625.21

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 9522.75 9540.53 9833.59 0.0 0.05 0.04
7h 8390.47 8334.56 8203.93 -0.01 -0.03 -0.02
23h 8707.08 2311.76 4591.78 -1.91 -0.92 0.99

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 9522.75 8390.47 8707.08 -0.18 -0.13 0.05
Ebov 9540.53 8334.56 2311.76 -0.19 -2.05 -1.85
Marv 9833.59 8203.93 4591.78 -0.26 -1.1 -0.84

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 7161.52 6835.55 7405.17 -0.07 0.05 0.12
7h 6740.6 7043.52 7168.36 0.06 0.09 0.03
23h 5005.64 5842.04 5884.29 0.22 0.23 0.01

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 7161.52 6740.6 5005.64 -0.09 -0.52 -0.43
Ebov 6835.55 7043.52 5842.04 0.04 -0.23 -0.27
Marv 7405.17 7168.36 5884.29 -0.05 -0.33 -0.28