PIM1

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
PIM1	PIM	Pim-1 proto-oncogene, serine/threonine kinase		pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.

This gene is expressed in human and bat in all probes. In Ebola infected probes it is almost three times upregulated after 23h in human, but downregulated in bat. In contrast to that, in Marburg infected probes it is downregulated in human after 23h, but upregulated in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	22	24	25	23	32	125	39	59	43
Read_Max	R. aegyptiacus	Transcriptome	35	58	40	54	58	56	29	48	63
Read_Max	R. aegyptiacus	Genome	52	47	32	44	47	34	21	64	64
DESeq	H. sapiens	Genome	199.9	237.61	245.23	281.61	287.97	1012.94	367.67	464.62	502.27
DESeq	R. aegyptiacus	Transcriptome	190.03	237.0	281.95	226.25	322.96	285.87	146.73	240.6	286.16
DESeq	R. aegyptiacus	Genome	418.52	395.19	453.01	441.41	648.47	608.32	360.97	497.18	550.53

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	199.9	281.61	367.67	0.49	0.88	0.38
7h	237.61	287.97	464.62	0.28	0.97	0.69
23h	245.23	1012.94	502.27	2.05	1.03	-1.01

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	199.9	237.61	245.23	0.25	0.29	0.05
Ebov	281.61	287.97	1012.94	0.03	1.85	1.81
Marv	367.67	464.62	502.27	0.34	0.45	0.11

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	190.03	226.25	146.73	0.25	-0.37	-0.62
7h	237.0	322.96	240.6	0.45	0.02	-0.42
23h	281.95	285.87	286.16	0.02	0.02	0.0

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	190.03	237.0	281.95	0.32	0.57	0.25
Ebov	226.25	322.96	285.87	0.51	0.34	-0.18
Marv	146.73	240.6	286.16	0.71	0.96	0.25

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material