PIM1

NameSynonymsFull NameRefSeq IDDescription (.pdf)IGV-img (humangenome)Sashimi-img (humangenome)UCSC-img (humangenome)IGV-img (batgenome)
PIM1 PIM Pim-1 proto-oncogene, serine/threonine kinase pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

The protein encoded by this gene belongs to the Ser/Thr protein kinase family, and PIM subfamily. This gene is expressed primarily in B-lymphoid and myeloid cell lines, and is overexpressed in hematopoietic malignancies and in prostate cancer. It plays a role in signal transduction in blood cells, contributing to both cell proliferation and survival, and thus provides a selective advantage in tumorigenesis. Both the human and orthologous mouse genes have been reported to encode two isoforms (with preferential cellular localization) resulting from the use of alternative in-frame translation initiation codons, the upstream non-AUG (CUG) and downstream AUG codons.

This gene is expressed in human and bat in all probes. In Ebola infected probes it is almost three times upregulated after 23h in human, but downregulated in bat. In contrast to that, in Marburg infected probes it is downregulated in human after 23h, but upregulated in bat.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source Species Mapping on Mock3h Mock7h Mock23h EBOV3h EBOV7h EBOV23h MARV3h MARV7h MARV23h
Read_Max
humanH. sapiensGenome22 24 25 23 32 125 39 59 43
Read_Max
batR. aegyptiacusTranscriptome 35 58 40 54 58 56 29 48 63
Read_Max
bat_genomeR. aegyptiacusGenome 52 47 32 44 47 34 21 64 64
DESeq
humanH. sapiensGenome 199.9 237.61 245.23 281.61 287.97 1012.94 367.67 464.62 502.27
DESeq
batR. aegyptiacusTranscriptome 190.03 237.0 281.95 226.25 322.96 285.87 146.73 240.6 286.16
DESeq
bat_genomeR. aegyptiacusGenome 418.52 395.19 453.01 441.41 648.47 608.32 360.97 497.18 550.53

Human Condition Comparisons

human Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 199.9 281.61 367.67 0.49 0.88 0.38
7h 237.61 287.97 464.62 0.28 0.97 0.69
23h 245.23 1012.94 502.27 2.05 1.03 -1.01

Human Time Point Comparisons

human 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 199.9 237.61 245.23 0.25 0.29 0.05
Ebov 281.61 287.97 1012.94 0.03 1.85 1.81
Marv 367.67 464.62 502.27 0.34 0.45 0.11

Bat Condition Comparisons

bat Mock EBOV MARV FCMock_EBOV FCMock_MARV FCEBOV_MARV
3h 190.03 226.25 146.73 0.25 -0.37 -0.62
7h 237.0 322.96 240.6 0.45 0.02 -0.42
23h 281.95 285.87 286.16 0.02 0.02 0.0

Bat Time Point Comparisons

bat 3h 7h 23h FC3h_7h FC3h_23h FC7h_23h
Mock 190.03 237.0 281.95 0.32 0.57 0.25
Ebov 226.25 322.96 285.87 0.51 0.34 -0.18
Marv 146.73 240.6 286.16 0.71 0.96 0.25