TRAF4

Name	Synonyms	Full Name	RefSeq ID	Description (.pdf)	IGV-img (human_genome)	Sashimi-img (human_genome)	UCSC-img (human_genome)	IGV-img (bat_genome)
TRAF4	MLN 62, CART1, RNF83,CART1, MLN62	TNF receptor-associated factor 4	NM_145751	pdf

Download all snapshots for IGV, UCSC and Sashimi (zip archive)

Description

This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.

The gene TRAF4 is expressed throughout all datasets in human cells and bat cells without significant changes.

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Maximum read counts and DESeq normalized read counts for human and bat cell lines

Source	Species	Mapping on	Mock_3h	Mock_7h	Mock_23h	EBOV_3h	EBOV_7h	EBOV_23h	MARV_3h	MARV_7h	MARV_23h
Read_Max	H. sapiens	Genome	129	136	151	142	225	731	155	191	201
Read_Max	R. aegyptiacus	Transcriptome	38	40	65	56	59	97	38	59	136
Read_Max	R. aegyptiacus	Genome	44	58	58	39	48	63	32	73	135
DESeq	H. sapiens	Genome	1902.71	2171.29	1989.63	2203.66	2029.31	8178.14	2309.8	2558.92	2609.55
DESeq	R. aegyptiacus	Transcriptome	211.04	272.4	636.2	394.74	385.38	572.02	269.09	422.37	651.78
DESeq	R. aegyptiacus	Genome	261.25	394.28	692.9	312.04	420.78	644.87	294.63	413.92	678.1

Human Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	1902.71	2203.66	2309.8	0.21	0.28	0.07
7h	2171.29	2029.31	2558.92	-0.1	0.24	0.33
23h	1989.63	8178.14	2609.55	2.04	0.39	-1.65

Human Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	1902.71	2171.29	1989.63	0.19	0.06	-0.13
Ebov	2203.66	2029.31	8178.14	-0.12	1.89	2.01
Marv	2309.8	2558.92	2609.55	0.15	0.18	0.03

Bat Condition Comparisons

	Mock	EBOV	MARV	FC_{Mock_EBOV}	FC_{Mock_MARV}	FC_{EBOV_MARV}
3h	211.04	394.74	269.09	0.9	0.35	-0.55
7h	272.4	385.38	422.37	0.5	0.63	0.13
23h	636.2	572.02	651.78	-0.15	0.03	0.19

Bat Time Point Comparisons

	3h	7h	23h	FC_{3h_7h}	FC_{3h_23h}	FC_{7h_23h}
Mock	211.04	272.4	636.2	0.37	1.59	1.22
Ebov	394.74	385.38	572.02	-0.03	0.54	0.57
Marv	269.09	422.37	651.78	0.65	1.28	0.63

Differential transcriptional responses to Ebola and Marburg virus infection in cells from bats and humans

Supplemental Material